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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Features of a large epidemic of group a meningococcal meningitis in Khartoum, Sudan in 1988
Scandinavian Journal of Infectious Diseases, Volume 22, No. 2, Year 1990
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Description
A large epidemic (February-August 1988) of group A sulphonamide resistant, clone III-1 menin-gococcal meningitis in Khartoum, Sudan is described. A total of 10099 cases were admitted to treatment centers with 8397 cases during March and April, corresponding to an annual incidence of 1679/100000 inhabitants during this period. The age profile showed a high morbidity in adults (31% of the cases > 20 years). The male dominance was marked especially in the adult cases with a proportion of 3.2:1. The epidemic started during the hot and dry season and decline when the clouds came, humidity rose, temperature fell and a mass vaccination campaign had been implemented together with other epidemic precautions. Vaccination with a combined group A/C poly-saccharide vaccine had been given 4 weeks-1 year before hospitalization to 11% of the children, 80% of whom were >18 months of age. The estimated case fatality rate was 6.3% Since 47% of the cases came from periurban and rural areas, the actual mortality during the epidemic might have been higher when considering those who may have died before reaching any of the treatment centres. Fatal cases had a short history of acute illness and a septic condition. Septicaemia was rare and seen in only 3.7% of the cases, the rest had acute purulent meningitis. Hearing loss/impairment and hemiplegia was diagnosed in 2-3% of the cases. The epidemiology, based on detailed typing/subtyping and restriction enzyme patterns of meningococcal strains, was apparently associated with the Mecca outbreak in August 1987. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Authors & Co-Authors
Salih, Mustafa Abdalla M.
Sudan, Khartoum
Khartoum University
Ahmed, H.
Sudan, Khartoum
Khartoum University
Karrar, Zein Al A.A.R.
Sudan, Khartoum
Khartoum University
Kamil, I.
Sudan, Khartoum
Khartoum University
Osman, Khaled A.
Sudan
University Paediatric Ward c2
Palmgren, H.
Sweden, Umea
Norrlands Universitetssjukhus
Hofvander, Yngve
Sweden, Orebro
Universitetssjukhuset Örebro
Olcén, Per Olof
Sweden, Orebro
Universitssjukhuset Örebro
Statistics
Citations: 38
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.3109/00365549009037897
ISSN:
00365548
Research Areas
Disability
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Sudan
Participants Gender
Male