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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
A spiroketal-enol ether derivative from Tanacetum vulgare selectively inhibits HSV-1 and HSV-2 glycoprotein accumulation in vero cells
Antiviral Research, Volume 119, Article 3616, Year 2015
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Description
Abstract The inhibitory effects of Tanacetum vulgare rhizome extracts on HSV-1 and HSV-2 in vitro replication were assessed. Unlike extracts obtained from the aerial parts, adsorption inhibition and virucidal activities seemed not to be relevant for the observed antiviral action of tansy rhizome extracts. Instead, the most significant effects were the inhibition of virus penetration and a novel mechanism consisting of the specific arrest of viral gene expression and consequently the decrease of viral protein accumulation within infected cells. Through a bioactivity-guided fractionation protocol we isolated and identified the spiroketal-enol ether derivative (E)-2-(2,4-hexadiynyliden)-1,6-dioxaspiro[4.5]dec-3-ene as the active compound responsible for this inhibitory effect. © 2015 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Habtemariam, Solomon
United Kingdom, London
University of Greenwich
Abdel Moneim, Ahmed Esmat
Spain, Oviedo
Universidad de Oviedo
Melón García, Santiago
Spain, Oviedo
Hospital Universitario Central de Asturias
Dalton, Kevin P.
Spain, Oviedo
Universidad de Oviedo
Parra, Francisco
Spain, Oviedo
Universidad de Oviedo
Statistics
Citations: 29
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.antiviral.2015.04.004
ISSN:
01663542
Research Areas
Genetics And Genomics