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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Synthesis, crystal structure, quantum chemical calculations, DNA interactions, and antimicrobial activity of [Ag(2-amino-3-methylpyridine)
2
]NO
3
and [Ag(pyridine-2-carboxaldoxime)NO
3
]
Inorganic Chemistry, Volume 49, No. 21, Year 2010
Notification
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Description
[Ag(2-amino-3-methylpyridine)2]NO3 (1) and [Ag(pyridine-2-carboxaldoxime)NO3] (2) were prepared from corresponding ligands and AgNO3 in water/ethanol solutions, and the products were characterized by IR, elemental analysis, NMR, and TGA. The X-ray crystal structures of the two compounds show that the geometry around the silver(I) ion is bent for complex 1 with nitrate as an anion and trigonal planar for complex 2 with nitrate coordinated. ESI-MS results of solutions of 2 indicate the independent existence in solution of the [Ag(pyridine-2- carboxaldoxime)]+ ion. The geometries of the complexes are well described by DFT calculations using the ZORA relativistic approach. The compounds were tested against 14 different clinically isolated and four ATCC standard bacteria and yeasts and also compared with 17 commonly used antibiotics. Both 1 and 2 exhibited considerable activity against S. lutea, M. lutea, and S. aureus and against the yeast Candida albicans, while 2-amino-3-methylpyridine is slightly active and pyridine-2-carboxaldoxime shows no antimicrobial activity. In addition, the interaction of these metal complexes with DNA was investigated. Both 1 and 2 bind to DNA and reduce its electrophoretic mobility with different patterns of migration, while the ligands themselves induce no change. © 2010 American Chemical Society.
Authors & Co-Authors
Abu-Youssef, Morsy A.M.
Egypt, Alexandria
Faculty of Science
Soliman, Saied M.
Egypt, Alexandria
Faculty of Science
Langer, Vratislav
Sweden, Gothenburg
Chalmers University of Technology
Gohar, Yousry Mahmoud
Egypt, Alexandria
Faculty of Science
Hasanen, Ahmed A.
Egypt, Alexandria
Faculty of Science
Makhyoun, Mohamed A.
Egypt, Alexandria
Faculty of Science
Zaky, Amira H.
Egypt, Alexandria
Faculty of Science
Öhrström, Lars R.
Sweden, Gothenburg
Chalmers University of Technology
Statistics
Citations: 64
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1021/ic100581k
ISSN:
00201669
Research Areas
Environmental
Genetics And Genomics