Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Field applicability of a rapid-format anti-Ov-16 antibody test for the assessment of onchocerciasis control measures in regions of endemicity
Journal of Infectious Diseases, Volume 194, No. 2, Year 2006
Notification
URL copied to clipboard!
Description
Background. A previously developed, specific, rapid-format immunochromatographic card test that detects immunoglobulin G4 to the recombinant Onchocerca volvulus antigen Ov-16 was modified to detect antibodies in whole blood. Methods. Ov-16 card test results were assessed in 1511 subjects ≥ 2 years of age in 7 West African villages with varying histories of onchocerciasis control measures. Results. In villages in which control measures had been implemented, anti-Ov-16 antibody prevalence rates ranged from 5.2% to 65.1%. Antibody prevalence rates were close to zero among subjects born after effective control measures had been implemented. In 2 villages without a history of control measures where onchocerciasis was endemic, microfilariae (MF) prevalence rates were 82.8% and 65.1%, and antibody prevalence rates were 73.1% and 62.1%. In these 2 villages, the sensitivity of the Ov-16 card test was 81.1% and 76.5%, the specificity was 100%, and the positive predictive value was 91.8% and 80.5%. MF and antibody prevalence rates were correlated (Spearman's r = 0.815; P < .038). Conclusions. The Ov-16 card test is field applicable, exhibits high sensitivity and specificity for O. volvulus infection, and has great potential as a tool for surveillance and for evaluating the success of onchocerciasis control measures. © 2006 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Lipner, Ettie M.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Dembélé, Noumouzan
Switzerland, Geneva
Organisation Mondiale de la Santé
Souleymane, Sanou
Burkina Faso, Ouagadougou
Ministere de la Sante Ouagadougou
Alley, W. S.
Switzerland, Geneva
Organisation Mondiale de la Santé
Prevots, D. Rebecca
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Toè, Laurent D.
Switzerland, Geneva
Organisation Mondiale de la Santé
Boatin, Boakye A.
Switzerland, Geneva
Organisation Mondiale de la Santé
Weil, Gary J.
United States, St. Louis
Washington University School of Medicine in St. Louis
Nutman, B. Thomas
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
United States, Bethesda
National Institutes of Health Nih
Statistics
Citations: 86
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1086/505081
ISSN:
00221899
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study