Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Additive contribution of HLA class I alleles in the immune control of HIV-1 infection
Journal of Virology, Volume 84, No. 19, Year 2010
Notification
URL copied to clipboard!
Description
Previous studies have identified a central role for HLA-B alleles in influencing control of HIV infection. An alternative possibility is that a small number of HLA-B alleles may have a very strong impact on HIV disease outcome, dominating the contribution of other HLA alleles. Here, we find that even following the exclusion of subjects expressing any of the HLA-B class I alleles (B*57, B*58, and B*18) identified to have the strongest influence on control, the dominant impact of HLA-B alleles on virus set point and absolute CD4 count variation remains significant. However, we also find that the influence of HLA on HIV control in this C-clade-infected cohort from South Africa extends beyond HLA-B as HLA-Cw type remains a significant predictor of virus and CD4 count following exclusion of the strongest HLA-B associations. Furthermore, there is evidence of inter-dependent protective effects of the HLA-Cw*0401-B*8101, HLA-Cw*1203-B*3910, and HLA-A*7401-B*5703 haplotypes that cannot be explained solely by linkage to a protective HLA-B allele. Analysis of individuals expressing both protective and detrimental alleles shows that even the strongest HLA alleles appear to have an additive rather than dominant effect on HIV control at the individual level. Finally, weak but significant frequency-dependent effects in this cohort can be detected only by looking at an individual's combined HLA allele frequencies. Taken together, these data suggest that although individual HLA alleles, particularly HLA-B, can have a strong impact, HIV control overall is likely to be influenced by the additive effect of some or all of the other HLA alleles present. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Leslie, Alasdair J.
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
Matthews, Philippa C.
United Kingdom, Oxford
Nuffield Department of Medicine
Listgarten, Jennifer
United States, Redmond
Microsoft Research
Carlson, Jonathan M.
United States, Redmond
Microsoft Research
Kadie, Carl M.
United States, Redmond
Microsoft Research
Ndung'u, Thumbi P.
South Africa, Durban
University of Kwazulu-natal
Brander, Christian
Spain, Badalona
Hospital Universitari Germans Trias I Pujol
Coovadia, Hoosen Mahomed
South Africa, Durban
University of Kwazulu-natal
Walker, Bruce D.
South Africa, Durban
University of Kwazulu-natal
United States, Boston
Massachusetts General Hospital
United States, Chevy Chase
Howard Hughes Medical Institute
Heckerman, David E.
United States, Redmond
Microsoft Research
Goulder, Philip Jeremy Renshaw
United Kingdom, Oxford
Nuffield Department of Medicine
South Africa, Durban
University of Kwazulu-natal
United States, Boston
Massachusetts General Hospital
Statistics
Citations: 178
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1128/JVI.00320-10
ISSN:
0022538X
e-ISSN:
10985514
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cohort Study
Study Locations
South Africa