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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
In vitro antiplasmodial activity of some plants used in Kisii, Kenya against malaria and their chloroquine potentiation effects
Journal of Ethnopharmacology, Volume 84, No. 2-3, Year 2003
Notification
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Description
Fifty-five organic and aqueous extracts of 11 plants used in malaria therapy in Kisii District, Kenya were tested in vitro against chloroquine (CQ)-sensitive and resistant strains of Plasmodium falciparum. Of the plants tested, 73% were active (IC50<100 μg/ml). Three plants, Vernonia lasiopus, Rhamnus prinoides and Ficus sur afforded extracts with IC50 values ranging less than 30 μg/ml against both CQ-sensitive and resistant strains. Combination of some extracts with CQ against the multi-drug resistant P. falciparum isolate V1/S revealed some synergistic effect. The plant extracts with low IC50 values may be used as sources for novel antimalarial compounds to be used alone or in combination with CQ. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
Authors & Co-Authors
Muregi, Francis Wamakima
Kenya, Nairobi
Kenyatta University
Chhabra, Sumesh Chander
Kenya, Nairobi
Kenyatta University
Njagi, Eliud Nyaga Mwaniki
Kenya, Nairobi
Kenyatta University
Lang'at-Thoruwa, C. C.
Kenya, Nairobi
Kenyatta University
Njue, W. M.
Kenya, Nairobi
Kenyatta University
Orago, Alloys S.S.
Kenya, Nairobi
Kenyatta University
Omar, Sabah Ahmed
Kenya, Nairobi
Kenya Medical Research Institute
Ndiege, Isaiah Omolo
Kenya, Nairobi
Kenyatta University
Statistics
Citations: 132
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1016/S0378-8741(02)00327-6
ISSN:
03788741
Research Areas
Infectious Diseases
Study Locations
Kenya