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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Structure of the fungal β-glucan-binding immune receptor dectin-1: Implications for function
Protein Science, Volume 16, No. 6, Year 2007
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Description
The murine molecule dectin-1 (known as the β-glucan receptor in humans) is an immune cell surface receptor implicated in the immunological defense against fungal pathogens. Sequence analysis has indicated that the dectin-1 extracellular domain is a C-type lectin-like domain, and functional studies have established that it binds fungal β-glucans. We report several dectin-1 crystal structures, including a high-resolution structure and a 2.8 Å resolution structure in which a short soaked natural β-glucan is trapped in the crystal lattice. In vitro characterization of dectin-1 in the presence of its natural ligand indicates higher-order complex formation between dectin-1 and β-glucans. These combined structural and biophysical data considerably extend the current knowledge of dectin-1 structure and function, and suggest potential mechanisms of defense against fungal pathogens. Published by Cold Spring Harbor Laboratory Press. Copyright © 2007 The Protein Society.
Authors & Co-Authors
Brown, James
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
O'Callaghan, Christopher Anthony
Unknown Affiliation
Marshall, Andrew S.J.
United Kingdom, Oxford
Sir William Dunn School of Pathology
Gilbert, Robert J.C.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Siebold, Christian
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Gordon, Siamon
United Kingdom, Oxford
Sir William Dunn School of Pathology
Brown, Gordon D.A.
South Africa, Cape Town
Faculty of Health Sciences
Jones, Edith Yvonne
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Statistics
Citations: 157
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1110/ps.072791207
ISSN:
09618368
e-ISSN:
1469896X