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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 infection in reactive lymphoid tissues: A model for KSHV/HHV-8-related lymphomas?
Human Pathology, Volume 37, No. 1, Year 2006
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Description
We set out to analyze the presence of Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 (HHV-8) in different neoplasms occurring in East Africa, a region characterized by a high KSHV/HHV-8 seroprevalence rate and endemic Kaposi's sarcoma (KS). Our results suggest that, in endemic regions of Africa, KSHV/HHV-8 is predominantly associated with KS, independently of HIV status. During the course of this study, other important information came to light. We found the presence of KSHV/HHV-8 in 2 cases of lymph nodes partially involved by Burkitt's lymphoma and KS and in 1 case of multicentric Castleman disease. Our immunophenotypic and molecular data seem to suggest 2 different mechanisms of viral infection are at work in lymphoid cells. On one hand, when B cells show a latent phase infection with KSHV/HHV-8, after the germinal center reaction, naive B cells become resting memory B cells, similarly to Epstein-Barr virus-infected B cells. On the other hand, when lytic genes such as vIL6 are expressed in naive B cells, they may be driven to differentiate into plasmablasts without undergoing germinal center reaction. Interestingly, among KSHV/HHV-8-positive cases, in those in which there was also lymphoma, the neoplastic cells were negative for KSHV/HHV-8. This further confirms that KSHV/HHV-8 is involved in the neoplastic transformation of only certain types of lymphoma, probably in relation to their precursor infected cell. In conclusion, the maturation stage of KSHV/HHV-8-positive B cells as well as the type of viral infection may well determine the morphological, phenotypic, and clinical characteristics of KSHV/HHV-8-associated lymphomas. © 2006 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Lazzi, S.
Italy, Siena
Università Degli Studi Di Siena
Bellan, Cristiana
Italy, Siena
Università Degli Studi Di Siena
Amato, Teresa
Italy, Siena
Università Degli Studi Di Siena
Palummo, Nazzareno
Italy, Siena
Università Degli Studi Di Siena
Cardone, Concetta
Italy, Siena
Università Degli Studi Di Siena
D'Amuri, Alessandro
Italy, Siena
Università Degli Studi Di Siena
De Luca, Fabio
Italy, Siena
Università Degli Studi Di Siena
Beyanga, Medard
Tanzania, Mwanza
Bugando Medical Center
Facchetti, Fabio
Italy, Brescia
Spedali Civili Di Brescia
Tosi, Piero
Italy, Siena
Università Degli Studi Di Siena
Leoncini, L.
Italy, Siena
Università Degli Studi Di Siena
Italy, Siena
Azienda Ospedaliera Universitaria Senese
Statistics
Citations: 22
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1016/j.humpath.2005.08.020
ISSN:
00468177
Research Areas
Cancer
Infectious Diseases
Study Locations
Multi-countries