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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
neuroscience
Adolescent Development of Cortical and White Matter Structure in the NCANDA Sample: Role of Sex, Ethnicity, Puberty, and Alcohol Drinking
Cerebral Cortex, Volume 26, No. 10, Year 2016
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Description
Brain structural development continues throughout adolescence, when experimentation with alcohol is often initiated. To parse contributions from biological and environmental factors on neurodevelopment, this study used baseline National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) magnetic resonance imaging (MRI) data, acquired in 674 adolescents meeting no/low alcohol or drug use criteria and 134 adolescents exceeding criteria. Spatial integrity of images across the 5 recruitment sites was assured by morphological scaling using Alzheimer's disease neuroimaging initiative phantom-derived volume scalar metrics. Clinical MRI readings identified structural anomalies in 11.4%. Cortical volume and thickness were smaller and white matter volumes were larger in older than in younger adolescents. Effects of sex (male > female) and ethnicity (majority > minority) were significant for volume and surface but minimal for cortical thickness. Adjusting volume and area for supratentorial volume attenuated or removed sex and ethnicity effects. That cortical thickness showed age-related decline and was unrelated to supratentorial volume is consistent with the radial unit hypothesis, suggesting a universal neural development characteristic robust to sex and ethnicity. Comparison of NCANDA with PING data revealed similar but flatter, age-related declines in cortical volumes and thickness. Smaller, thinner frontal, and temporal cortices in the exceeds-criteria than no/low-drinking group suggested untoward effects of excessive alcohol consumption on brain structural development. © 2015 The Author 2015. Published by Oxford University Press. All rights reserved.
Authors & Co-Authors
Pfefferbaum, Adolf
United States, Menlo Park
Sri International
United States, Stanford
Stanford University School of Medicine
Rohlfing, Torsten
United States, Menlo Park
Sri International
United States, Mountain View
Google Llc
Pohl, Kilian M.
United States, Menlo Park
Sri International
United States, Stanford
Stanford University School of Medicine
Kwon, Dongjin
United States, Menlo Park
Sri International
Brown, Sandra A.
United States, La Jolla
University of California, San Diego
Tapert, Susan Frances
United States, La Jolla
University of California, San Diego
United States, San Diego
Va San Diego Healthcare System
Thompson, Wesley Kurt
United States, La Jolla
University of California, San Diego
Brumback, Ty Y.
United States, La Jolla
University of California, San Diego
Jernigan, Terry L.
United States, La Jolla
University of California, San Diego
Dale, Anders M.
United States, La Jolla
University of California, San Diego
Colrain, Ian M.
United States, Menlo Park
Sri International
Baker, Fiona C.
United States, Menlo Park
Sri International
Prouty, Devin E.
United States, Menlo Park
Sri International
de Bellis, Michael D.
United States, Durham
Duke University School of Medicine
Clark, Duncan B.
United States, Pittsburgh
University of Pittsburgh
Nagel, Bonnie J.
United States, Portland
Oregon Health & Science University
United States, Portland
Ohsu School of Medicine
Sullivan, Edith V.
United States, Stanford
Stanford University School of Medicine
Statistics
Citations: 91
Authors: 17
Affiliations: 9
Identifiers
Doi:
10.1093/cercor/bhv205
ISSN:
10473211
Research Areas
Substance Abuse
Participants Gender
Male
Female