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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Serum Uric Acid level and cardiovascular risks in hemodialysis patients: An Algerian cohort study
Pakistan Journal of Biological Sciences, Volume 16, No. 17, Year 2013
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Description
Elevated Serum Uric Acid (SUA) was usually associated with an increased risk of cardiovascular events and mortality in general population. However, there are few reports concerning the clinical impact and the pathogenic role of Uric Acid (UA) in Hemodialysis (HD) patients. The aim of the study was to investigate the relationship between SUA and various Cardiovascular (CV) risk factors in HD patients. This retrospective; observational cohort study includes 45 HD patients with a mean age of 51.26±15.21 years. The differences of the CV risk factors between the patients according to their SUA levels were investigated. Age, Cardiovascular Diseases (CVD), increased creatinine, Fasting Blood Glucose (FBG), Corrected Calcium (cCa), Phosphate (P), cCa x P product and LDL cholesterol levels were associated with lower SUA levels, whereas higher SUA level was associated with Diabetes Mellitus (DM), hypertension and increased triglycerides level (p<0.01). In multiple regression analysis, history of diabetes (β = 0.360, p<0.05), reduced corrected serum calcium (cCa) (β = -1.456, p<0.01) and Phosphate (P) levels (β = -1.752, p<0.01) were predictive of an increased SUA concentration. Despite from what has been demonstrated in the general population and DM patients, a lower SUA level in HD patients was associated with higher cardiovascular risk factors and high co-morbidity burden. Moreover, higher SUA concentrations may be cardioprotective in dialysis patients. © 2013 Asian Network for Scientific Information.
Authors & Co-Authors
Gouri, Adel
Algeria, Guelma
Hôpital Ibn Zohr Guelma
Dekaken, Aoulia
Algeria, Algeria
El Okbi Hospital
Bentorki, Ahmed Aimen
Algeria, Guelma
Hôpital Ibn Zohr Guelma
Touaref, Amel
Algeria, Guelma
Hôpital Ibn Zohr Guelma
Yekhlef, Amina
Algeria, Guelma
Hôpital Ibn Zohr Guelma
Sekkache, Fouzia
Algeria, Guelma
Hôpital Ibn Zohr Guelma
Kouicem, Nabila
Algeria, Guelma
Hôpital Ibn Zohr Guelma
Statistics
Citations: 7
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.3923/pjbs.2013.852.858
e-ISSN:
18125735
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative