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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Combined Inflammatory and Metabolic Defects Reflected by Reduced Serum Protein Levels in Patients with Buruli Ulcer Disease
PLoS Neglected Tropical Diseases, Volume 8, No. 4, Article e2786, Year 2014
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Description
Buruli ulcer is a skin disease caused by Mycobacterium ulcerans that is spreading in tropical countries, with major public health and economic implications in West Africa. Multi-analyte profiling of serum proteins in patients and endemic controls revealed that Buruli ulcer disease down-regulates the circulating levels of a large array of inflammatory mediators, without impacting on the leukocyte composition of peripheral blood. Notably, several proteins contributing to acute phase reaction, lipid metabolism, coagulation and tissue remodelling were also impacted. Their down-regulation was selective and persisted after the elimination of bacteria with antibiotic therapy. It involved proteins with various functions and origins, suggesting that M. ulcerans infection causes global and chronic defects in the host's protein metabolism. Accordingly, patients had reduced levels of total serum proteins and blood urea, in the absence of signs of malnutrition, or functional failure of liver or kidney. Interestingly, slow healers had deeper metabolic and coagulation defects at the start of antibiotic therapy. In addition to providing novel insight into Buruli ulcer pathogenesis, our study therefore identifies a unique proteomic signature for this disease. © 2014 Phillips et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3983110/bin/pntd.0002786.s001.ppt
Authors & Co-Authors
Phillips, Richard Odame
Unknown Affiliation
Sarfo, Fred Stephen
Unknown Affiliation
Landier, Jordi
Unknown Affiliation
Oldenburg, Reid
Unknown Affiliation
Frimpong, Michael
Unknown Affiliation
Wansbrough-Jones, Mark H.
Unknown Affiliation
Abass, Kabiru Mohammed
Unknown Affiliation
Thompson, William A.
Unknown Affiliation
Forson, Mark
Unknown Affiliation
Fontanet, A. L.
Unknown Affiliation
Niang, Fatoumata
Unknown Affiliation
Demangel, Caroline
Unknown Affiliation
Statistics
Citations: 23
Authors: 12
Affiliations: 10
Identifiers
Doi:
10.1371/journal.pntd.0002786
ISSN:
19352727
e-ISSN:
19352735
Research Areas
Food Security
Noncommunicable Diseases
Study Locations
Multi-countries