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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The systematic functional analysis of plasmodium protein kinases identifies essential regulators of mosquito transmission
Cell Host and Microbe, Volume 8, No. 4, Year 2010
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Description
Although eukaryotic protein kinases (ePKs) contribute to many cellular processes, only three Plasmodium falciparum ePKs have thus far been identified as essential for parasite asexual blood stage development. To identify pathways essential for parasite transmission between their mammalian host and mosquito vector, we undertook a systematic functional analysis of ePKs in the genetically tractable rodent parasite Plasmodium berghei. Modeling domain signatures of conventional ePKs identified 66 putative Plasmodium ePKs. Kinomes are highly conserved between Plasmodium species. Using reverse genetics, we show that 23 ePKs are redundant for asexual erythrocytic parasite development in mice. Phenotyping mutants at four life cycle stages in Anopheles stephensi mosquitoes revealed functional clusters of kinases required for sexual development and sporogony. Roles for a putative SR protein kinase (SRPK) in microgamete formation, a conserved regulator of clathrin uncoating (GAK) in ookinete formation, and a likely regulator of energy metabolism (SNF1/KIN) in sporozoite development were identified. © 2010 Elsevier Inc.
Authors & Co-Authors
Tewari, Rita
United Kingdom, Nottingham
University of Nottingham
United Kingdom, London
Imperial College London
Straschil, Ursula
United Kingdom, Nottingham
University of Nottingham
United Kingdom, London
Imperial College London
Bateman, Alex G.
United Kingdom, Hinxton
Wellcome Sanger Institute
Böhme, Ulrike
United Kingdom, Hinxton
Wellcome Sanger Institute
Cherevach, Inna
United Kingdom, Hinxton
Wellcome Sanger Institute
Gong, Peng
United Kingdom, Nottingham
University of Nottingham
Pain, Arnab P.
United Kingdom, Hinxton
Wellcome Sanger Institute
Saudi Arabia, Thuwal
King Abdullah University of Science and Technology
Billker, Oliver
United Kingdom, London
Imperial College London
United Kingdom, Hinxton
Wellcome Sanger Institute
Statistics
Citations: 286
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1016/j.chom.2010.09.006
ISSN:
19313128
Research Areas
Genetics And Genomics
Sexual And Reproductive Health