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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Influence of migration on characteristics of type 2 diabetes in sub-Saharan Africans
Diabetes and Metabolism, Volume 40, No. 1, Year 2014
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Description
Aim: This study compared the clinical and biochemical characteristics and microvascular complications found in three groups of type 2 diabetes (T2D) patients: Africans living in Africa; African immigrants living in France; and Caucasians living in France. Methods: Diagnosed T2D Africans living in Cameroon (n= 100) were compared with 98 African migrants diagnosed with T2D after having moved to France, and a group of 199 T2D Caucasian patients living in France. All underwent clinical and biochemical evaluations, and all were assessed for microvascular complications. Results: The median duration of stay of the migrants in France was 15years before being diagnosed with diabetes. Despite similar durations of diagnosis, they were 8.9years younger at the time of diagnosis than Africans living in Cameroon (P<0.001). Caucasians and African immigrants in France had lower HbA1c values than Africans in Cameroon (P<0.001); they were also more aggressively treated for hypertension and dyslipidaemia and, therefore, had significantly lower blood pressure levels and better lipid profiles. Diabetic nephropathy and retinopathy rates were higher in Cameroon than in the two other groups. After adjusting for age, diabetes duration, HbA1c, hypertension and other covariates, only the prevalence of diabetic nephropathy (OR: 5.61, 95% CI: 2.32-13.53; P<0.0001) was higher in Cameroon compared with those living in France. Conclusion: Our results suggest that Africans who emigrate to France may develop diabetes earlier than those staying in their home country. However, the latter may be a reflection of late diagnosis of diabetes. Also, the less adequate diabetes and hypertension control in the latter would explain their higher rates of nephropathy. Large-scale cohorts are now warranted to substantiate these observations. © 2013 Elsevier Masson SAS.
Authors & Co-Authors
Choukem, Siméon Pierre
France, Paris
Hôpital Lariboisiere Ap-hp
Cameroon, Buea
University of Buea
Fabreguettes, C.
France, Paris
Hôpital Lariboisiere Ap-hp
Akwo, Elvis Abang
Cameroon, Yaounde
Central Hospital of Yaounde Fmbs
Porcher, Raphaël
France, Paris
Hôpital Saint-louis
Nguewa, Jean Louis
France, Paris
Hôpital Lariboisiere Ap-hp
Bouché, Clara H.
France, Paris
Hôpital Lariboisiere Ap-hp
Kaze, François Folefack
Cameroon, Yaounde
Université de Yaoundé I
Kengne, Andre-Pascal Pascal
South Africa, Tygerberg
South African Medical Research Council
Australia, Sydney
The University of Sydney
Vexiau, Patrick
France, Paris
Hôpital Lariboisiere Ap-hp
Mbanya, J. C.
Cameroon, Yaounde
Central Hospital of Yaounde Fmbs
Cameroon, Yaounde
Université de Yaoundé I
Sobngwi, Eugène
Cameroon, Yaounde
Central Hospital of Yaounde Fmbs
Cameroon, Yaounde
Université de Yaoundé I
Gautier, Jean François
France, Paris
Hôpital Lariboisiere Ap-hp
France, Paris
Centre de Recherche Des Cordeliers
Statistics
Citations: 25
Authors: 12
Affiliations: 8
Identifiers
Doi:
10.1016/j.diabet.2013.07.004
ISSN:
12623636
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Cameroon