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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Phenotypic characterization of HIV type 1 isolates from Ghana
AIDS Research and Human Retroviruses, Volume 23, No. 1, Year 2007
Notification
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Description
Viral isolates from 27 HIV-1-infected patients in Ghana, most of whom were symptomatic, were characterized for coreceptor usage using MT-2 and U87.CD4 cells. Irrespective of clinical status, most infections were caused by CCR5-tropic viruses although three CXCR4-tropic viruses were also found. Genotyping was performed by sequencing the gp41 region. Seven viruses clustered with subtype G reference strains, while the remaining 20 viruses clustered within the subtype A reference viruses. Most subtype A isolates clustered loosely with the CRF02_AG viruses and are described as CRF02_AG-like. The V3 loop was sequenced in selected isolates including all isolates capable of using CXCR4. The V3 region of CXCR4-using viruses contained genetic traits characteristic of CXCR4-using subtype B and C viruses, such as increased charge, the presence of positively charged residues at positions 11 and 25, and loss of a predicted glycosylation site. This study supports previous work showing that CRF02_AG is responsible for most HIV-1 infections in Ghana at this time. The predominance of CCR5-using viruses, even in symptomatic patients, suggests that CCR5-blocking strategies may be useful for prevention and treatment of HIV-1 infections in Ghana. © Mary Ann Liebert, Inc.
Authors & Co-Authors
Brandful, James Ashun Mensah
Ghana, Accra
Noguchi Memorial Institute for Medical Research
South Africa, Johannesburg
National Institute for Communicable Diseases
Coetzer, Mia E.
South Africa, Johannesburg
National Institute for Communicable Diseases
Cilliers, Tonie
South Africa, Johannesburg
National Institute for Communicable Diseases
Phoswa, Mary
South Africa, Johannesburg
National Institute for Communicable Diseases
Papathanasopoulos, Maria
South Africa, Johannesburg
National Institute for Communicable Diseases
South Africa, Johannesburg
School of Clinical Medicine
Morris, Lynn
South Africa, Johannesburg
National Institute for Communicable Diseases
Moore, Penny L.
Ghana, Accra
Noguchi Memorial Institute for Medical Research
South Africa, Johannesburg
National Institute for Communicable Diseases
Statistics
Citations: 13
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1089/aid.2007.23.144
ISSN:
08892229
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Ghana