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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
PTX3 Genetic Variation and Dizygotic Twinning in The Gambia: Could Pleiotropy with Innate Immunity Explain Common Dizygotic Twinning in Africa?
Annals of Human Genetics, Volume 76, No. 6, Year 2012
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Description
Dizygotic (DZ) twinning has a genetic component and is common among sub-Saharan Africans; in The Gambia its frequency is up to 3% of live births. Variation in PTX3, encoding Pentraxin 3, a soluble pattern recognition receptor that plays an important role both in innate immunity and in female fertility, has been associated with resistance to Mycobacterium tuberculosis pulmonary disease and to Pseudomonas aeruginosa infection in cystic fibrosis patients. We tested whether PTX3 variants in Gambian women associate with DZ twinning, by genotyping five PTX3 single nucleotide polymorphisms (SNPs) in 130 sister pairs (96 full sibs and 34 half sibs) who had DZ twins. Two, three and five SNP haplotypes differed in frequency between twinning mothers and those without a history of twinning (from P= 0.006 to 3.03e-06 for two SNP and three SNP haplotypes, respectively). Twinning mothers and West African tuberculosis-controls from a previous study shared several frequent haplotypes. Most importantly, our data are consistent with an independently reported association of PTX3 and female fertility in a sample from Ghana. Taken together, these results indicate that selective pressure on PTX3 variants that affect the innate immune response to infectious agents, could also produce the observed high incidence of DZ twinning in Gambians. © 2012 The Authors Annals of Human Genetics © 2012 Blackwell Publishing Ltd/University College London.
Authors & Co-Authors
Sirugo, G.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Italy, Rome
Ospedale San Pietro Fatebenefratelli
Edwards, Digna R.Velez
United States, Nashville
Vanderbilt University Medical Center
Ryckman, Kelli K.
United States, Nashville
Vanderbilt University Medical Center
United States, Iowa City
University of Iowa
Bisseyé, Cyrille
Gambia, Banjul
Medical Research Council Laboratories Gambia
White, Marquitta J.
United States, Nashville
Vanderbilt University Medical Center
Kebbeh, Bunja
Gambia, Banjul
Medical Research Council Laboratories Gambia
Morris, Gerard A.J.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Adegbola, Richard A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Belgium, Rixensart
Glaxosmithkline Biologicals S.a.
Tacconelli, Alessandra
Italy, Rome
Ospedale San Pietro Fatebenefratelli
Predazzi, Irene Marta
United States, Nashville
Vanderbilt University Medical Center
Novelli, Giuseppe
Italy, Rome
Ospedale San Pietro Fatebenefratelli
Italy, Rome
Facoltà Di Medicina e Chirurgia Università Degli Studi Di Roma Tor Vergata
Vannberg, Fredrik O.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Odunsi, Kunle O.
United States, Buffalo
Roswell Park Cancer Institute
Page, Grier P.
United States, Research Triangle Park
Rti International
Williams, Scott M.
United States, Nashville
Vanderbilt University Medical Center
United States, Hanover
Geisel School of Medicine at Dartmouth
Statistics
Citations: 15
Authors: 15
Affiliations: 10
Identifiers
Doi:
10.1111/j.1469-1809.2012.00723.x
e-ISSN:
14691809
Research Areas
Genetics And Genomics
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Study Locations
Gambia
Ghana
Participants Gender
Female