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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
First next-generation sequencing full-genome characterization of a hepatitis C virus genotype 7 divergent subtype
Clinical Microbiology and Infection, Volume 22, No. 11, Year 2016
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Description
We report the near-full-length genome sequence of a hepatitis C virus (HCV) isolate from a man originating from Democratic Republic of Congo, the genotype of which could not be determined by the routinely used sequencing technique. The near-complete genome sequence of this variant BAK1 was obtained by the association of two next-generation sequencing technologies. Evolutionary analysis indicates that this isolate, BAK1, could be the first reported strain belonging to a new HCV-7b subtype. This new subtype has been incorrectly identified as genotype 2 by the Versant HCV Genotype 2.0 assay (LiPA). The requirement of three independent isolates has been filled, and a new subtype can be assigned. More examples of HCV-7 are required to better understand its origin, its pathogenicity and its relationship with genotype 2. © 2016 European Society of Clinical Microbiology and Infectious Diseases
Authors & Co-Authors
Salmona, Maud
France, Paris
Hôpital Saint-louis
Simmonds, Peter N.
United Kingdom, Oxford
University of Oxford
Mercier-Delarue, Séverine
France, Paris
Hôpital Saint-louis
de Castro, Nathalie
France, Paris
Hôpital Saint-louis
Le-Goff, Jérôme
France, Paris
Hôpital Saint-louis
Chaix, Marie Laure
France, Paris
Hôpital Saint-louis
François, Olivier
France, La Tronche
Techniques for Biomedical Engineering and Complexity Management Informatics, Mathematics and Applications Grenoble Timc-imag
Simon, Franćois
France, Paris
Hôpital Saint-louis
Morand, Patrice
France, Grenoble
Centre Hospitalier Universitaire de Grenoble
France, Grenoble
Cea Grenoble
Maylin, Sarah
France, Paris
Hôpital Saint-louis
Statistics
Citations: 18
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1016/j.cmi.2016.07.032
ISSN:
1198743X
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Congo