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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The natural history of respiratory syncytial virus in a birth cohort: The influence of age and previous infection on reinfection and disease
American Journal of Epidemiology, Volume 176, No. 9, Year 2012
Notification
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Description
This study aimed to quantify the effect of age, time since last infection, and infection history on the rate of respiratory syncytial virus infection and the effect of age and infection history on the risk of respiratory syncytial virus disease. A birth cohort of 635 children in Kilifi, Kenya, was monitored for respiratory syncytial virus infections from January 31, 2002, to April 22, 2005. Predictors of infection were examined by Cox regression and disease risk by binomial regression. A total of 598 respiratory syncytial virus infections were identified (411 primary, 187 repeat), with 409 determined by antigen assay and 189 by antibody alone (using a "most pragmatic" serologic definition). The incidence decreased by 70 following a primary infection (adjusted hazard ratio 0.30, 95 confidence interval: 0.21, 0.42; P < 0.001) and by 59 following a secondary infection (hazard ratio 0.41, 95 confidence interval: 0.22, 0.73; P 0.003), for a period lasting 6 months. Relative to the age group <6 months, all ages exhibited a higher incidence of infection. A lower risk of severe disease following infection was independently associated with increasing age (P < 0.001) but not reinfection. In conclusion, observed respiratory syncytial virus incidence was lowest in the first 6 months of life, immunity to reinfection was partial and short lived, and disease risk was age related. © 2012 The Author.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3481264/bin/supp_176_9_794__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3481264/bin/supp_kws257_kws257_Web_Tables.pdf
Authors & Co-Authors
Ohuma, Eric O.
Kenya, Kilifi
Centre for Geographic Medicine Research
Okiro, Emelda Aluoch
Kenya, Kilifi
Centre for Geographic Medicine Research
Ochola, Rachel
Kenya, Kilifi
Centre for Geographic Medicine Research
Sande, Charles Jumba
Kenya, Kilifi
Centre for Geographic Medicine Research
Cane, Patricia A.
Kenya, Kilifi
Centre for Geographic Medicine Research
Medley, Graham F.
Kenya, Kilifi
Centre for Geographic Medicine Research
Bottomley, Christian
Kenya, Kilifi
Centre for Geographic Medicine Research
Nokes, David James
Kenya, Kilifi
Centre for Geographic Medicine Research
Statistics
Citations: 110
Authors: 8
Affiliations: 1
Identifiers
Doi:
10.1093/aje/kws257
ISSN:
00029262
e-ISSN:
14766256
Research Areas
Environmental
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Kenya