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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Short communication: Anti-HIV-1 envelope immunoglobulin gs in blood and cervicovaginal samples of beninese commercial sex workers
AIDS Research and Human Retroviruses, Volume 30, No. 11, Year 2014
Notification
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Description
Characterization of the immune correlates of protection against HIV infection is crucial for the development of preventive strategies. This study examined HIV-1 envelope (Env) glycoproteins, specifically immunoglobulin G (IgG), in systemic and mucosal compartments of female Beninese commercial sex workers (CSWs). Samples of 23 HIV-1-positive and 20 highly exposed HIV-1-seronegative (HESN) CSWs were studied. HIV-1 Env-specific IgG detection in sera and cervicovaginal lavages (CVLs) from the study population was done by cell-based ELISA. The HIV neutralizing activity was evaluated with a neutralization assay. The HIV-1-specific antibody-dependent cellular cytotoxicity (ADCC) response of the cohort was measured with a FACS-based assay evaluating the ADCC-mediated elimination of gp120-coated target cells. No anti-HIV-1 Env-specific IgG neutralizing or ADCC activities were detected in samples from HESN CSWs. Samples from HIV-1-infected CSWs presented ADCC activity in both sera and CVLs. Anti-Env IgG from sera and CVLs from HIV-1-infected CSWs preferentially recognized Env in its CD4-bound conformation. HIV-1-infected CSWs have ADCC-mediating IgG that preferentially recognizes Env in its CD4-bound conformation at the mucosal site. © 2014 Mary Ann Liebert, Inc.
Authors & Co-Authors
Veillette, Maxime
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Canada, Montreal
University of Montreal
Labbé, Annie Claude
Canada, Montreal
University of Montreal
Alary, Michel
Canada, Quebec
Chu de Québec-université Laval
Canada, Quebec
Université Laval
Guédou, Fernand Aimé
Unknown Affiliation
Kaufmann, Daniel Elias
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
United States, Cambridge
Massachusetts Institute of Technology
Poudrier, Johanne
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Canada, Montreal
University of Montreal
Finzi, Andrés
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Canada, Montreal
University of Montreal
Canada, Montreal
Université Mcgill
Roger, Michel
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Canada, Montreal
University of Montreal
Statistics
Citations: 23
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1089/aid.2014.0163
ISSN:
08892229
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Female