Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Male circumcision decreases acquisition and increases clearance of high-risk human papillomavirus in HIV-negative men: A randomized trial in Rakai, Uganda
Journal of Infectious Diseases, Volume 201, No. 10, Year 2010
Notification
URL copied to clipboard!
Description
Methods. Uncircumcised human immunodeficiency virus (HIV)-negative men aged 15-49 years were randomized to immediate circumcision (intervention arm, 441 subjects) or delayed circumcision (control arm, 399 subjects). Human papillomavirus (HPV) was detected by Roche HPV Linear Array at enrollment, and at 6, 12, and 24 months. Incident high-risk HPV (HR-HPV) was estimated in men who acquired a new HR-HPV genotype. HR-HPV clearance was determined in men with prior genotype-specific HR-HPV infections. Rate ratios (RRs) and 95% confidence intervals (CIs) of HR-HPV acquisition were estimated by Poisson multiple regression. Results. Enrollment characteristics were comparable between study groups. HR-HPV incidence was 19.7 cases per 100 person-years (PYs) in the intervention arm (70 cases per 355.8 PYs) and 29.4 cases per 100 PYs (125 cases per 424.8 PYs) in the control arm (RR, 0.67; 95% CI, 0.51-0.89; P = .006). The incidence of multiple HRHPV infections was 6.7 cases per 100 PYs in the intervention arm and 14.8 cases per 100 PYs in the control arm (RR, 0.45; 95% CI, 0.28-0.73), but there was no significant effect on single infections (RR, 0.89; 95% CI, 0.60-1.30). HR-HPV incidence was lower in the intervention arm for all genotypes and demographic/behavioral subgroups. The clearance of preexisting HR-HPV infections was 215.8 cases per 100 PYs (205 cases per 95 PYs) in the intervention arm and 159.1 cases per 100 PYs (255 cases per 160.25 PYs) in the control arm (adjusted RR, 1.39; 95% CI, 1.17-1.64). Conclusions. Male circumcision reduces the incidence of multiple HR-HPV infections and increases clearance of HR-HPV infections in HIV-uninfected men. Trial Registration. ClinicalTrials.gov identifier: NCT00425984. © 2010 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Gray, Ronald H.
Uganda, Kalisizo
Rakai Health Sciences Program
Serwadda, David Musoke
Uganda, Kalisizo
Rakai Health Sciences Program
Uganda, Kampala
School of Public Health
Kong, Xiangrong
Unknown Affiliation
Makumbi, Fredrick Edward
Uganda, Kalisizo
Rakai Health Sciences Program
Uganda, Kampala
School of Public Health
Kigozi, Godfrey G.
Uganda, Kalisizo
Rakai Health Sciences Program
Gravitt, Patti E.
Unknown Affiliation
Watya, Stephen
Uganda, Kampala
Mulago Hospital
Nalugoda, Fred Kakaire
Uganda, Kalisizo
Rakai Health Sciences Program
Ssempijja, Victor
Uganda, Kalisizo
Rakai Health Sciences Program
Tobian, Aaron A.R.
Unknown Affiliation
Kiwanuka, Noah
Uganda, Kalisizo
Rakai Health Sciences Program
Uganda, Kampala
School of Public Health
Moulton, Lawrence H.
United States, Baltimore
Johns Hopkins University
Sewankambo, Nelson K.
Uganda, Kalisizo
Rakai Health Sciences Program
Uganda, Kampala
Makerere University
Reynolds, Steven James
United States, Baltimore
Johns Hopkins Medical Institutions
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Quinn, Thomas Charles
United States, Baltimore
Johns Hopkins Medical Institutions
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Lga, Boaz
Uganda, Kalisizo
Rakai Health Sciences Program
Laeyendecker, Oliver B.
United States, Baltimore
Johns Hopkins Medical Institutions
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Oliver, Amy E.
United States, Baltimore
Johns Hopkins Medical Institutions
Wawer, Maria J.
Uganda, Kalisizo
Rakai Health Sciences Program
Statistics
Citations: 187
Authors: 19
Affiliations: 7
Identifiers
Doi:
10.1086/652184
ISSN:
00221899
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Randomised Control Trial
Cohort Study
Study Locations
Uganda
Participants Gender
Male