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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Avascular necrosis of the femoral head in adult Kuwaiti sickle cell disease patients
Acta Haematologica, Volume 110, No. 1, Year 2003
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Description
While sickle cell disease (SCD) is generally mild in most Kuwaitis, because of their elevated fetal Hb levels, avascular necrosis of the femoral head (AVNFH) appears to be a common complication. It was recently documented in 26.7% of Kuwaiti children with SCD. There have, however, been no previous studies of adult patients. This is a 1-year study of consecutive, steady-state SCD patients seen in the hematology clinic of Mubarak Al-Kabeer Hospital. The patients' charts were reviewed for frequency of hospitalizations, any documented complications and steady-state complete blood count (CBC). MRI was performed using T1- and T2-weighted FATSAT sequences in coronal and axial planes with 4-mm-thick slices on a 1.5-tesla GE super-conducting magnet. Thirty-five patients were studied, consisting of 25 SS and 10 Sβ 0Thal patients aged between 17 and 44, with a mean age of 26.7 ± 9.3 years. Seventeen (48.6%) had varying degrees of AVNFH; among the 70 hips examined, 29 (41.1%) were affected. Of the 17 patients affected, 11 (64.7%) were SS, while 6 (35.3%) were Sβ0Thal. There were 14 (82.4%) males and 3 (17.6%) females (χ2 = 8.6, p < 0.01). The mean age of those affected, 27.5 ± 10.7 years, was not significantly higher than that of the unaffected (26.3 ± 8.0 years). Eleven (64.7%) of those affected had a history of frequent vaso-occlusive crisis. No significant differences could be demonstrated in the mean CBC and Hb F values of the two groups; coexistent α-thal trait was not a factor in the SS group. Male gender was the only significant predisposing factor identified. While more patients with frequent vaso-occlusive crises were affected, the difference was not significant. AVNFH is, indeed, quite common among Kuwaiti SCD patients and there is a need for early institution of preventive and therapeutic protocols. Copyright © 2003 S. Karger AG, Basel.
Authors & Co-Authors
Marouf, R. A.R.
Kuwait, Kuwait City
Kuwait University
Gupta, Renu K.
Kuwait, Kuwait City
Kuwait University
Haider, Mohammad Zafaryab
Kuwait, Kuwait City
Kuwait University
Al Wazzan, Hanan
Kuwait, Kuwait City
Mubarak Hospital
Adekile, Adekunle D.
Kuwait, Kuwait City
Kuwait University
Statistics
Citations: 30
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1159/000072406
ISSN:
00015792
Research Areas
Health System And Policy
Maternal And Child Health
Participants Gender
Male
Female