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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Distribution of High-Risk Human Papillomavirus Genotypes among HIV-Negative Women with and without Cervical Intraepithelial Neoplasia in South Africa
PLoS ONE, Volume 7, No. 9, Article e44332, Year 2012
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Description
Objective: Large studies describing the profile of high-risk Human papillomavirus (hrHPV) genotypes among women in sub-Saharan Africa are lacking. Here we describe the prevalence and distribution of hrHPV genotypes among HIV-negative women in South Africa, with and without cervical intraepithelial neoplasia (CIN). Methods: We report data on 8,050 HIV-negative women, aged 17-65 years, recruited into three sequential studies undertaken in Cape Town, South Africa. Women had no history of previous cervical cancer screening. Cervical samples were tested for hrHPV DNA using the Hybrid Capture 2 (HC2) assay and all positive samples were genotyped using a PCR-based assay (Line Blot). Women underwent colposcopy and biopsy/endocervical curettage to determine CIN status. The prevalence and distribution of specific hrHPV genotypes were examined by age and CIN status. Results: Overall, 20.7% (95% CI, 19.9-21.6%) of women were hrHPV-positive by HC2, with women with CIN having the highest rates of positivity. Prevalence decreased with increasing age among women without CIN; but, a bimodal age curve was observed among women with CIN. HPV 16 and 35 were the most common hrHPV genotypes in all age and CIN groups. HPV 45 became more frequent among older women with CIN grade 2 or 3 (CIN2,3). Younger women (17-29 years) had more multiple hrHPV genotypes overall and in each cervical disease group than older women (40-65 years). Conclusion: HPV 16, 35, and 45 were the leading contributors to CIN 2,3. The current HPV vaccines could significantly reduce HPV-related cervical disease; however, next generation vaccines that include HPV 35 and 45 would further reduce cervical disease in this population. © 2012 McDonald et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3435398/bin/pone.0044332.s001.doc
Authors & Co-Authors
McDonald, Alicia C.
United States, New York
Mailman School of Public Health
Denny, Lynette A.
South Africa, Cape Town
University of Cape Town
Wang, Chunhui
United States, New York
Vagelos College of Physicians and Surgeons
Tsai, Wei Yann
United States, New York
Mailman School of Public Health
Wright, Thomas C.
United States, New York
Vagelos College of Physicians and Surgeons
Kuhn, Louise
United States, New York
Mailman School of Public Health
United States, New York
Gertrude H. Sergievsky Center
Statistics
Citations: 24
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pone.0044332
e-ISSN:
19326203
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
South Africa
Participants Gender
Female