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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Ecological Study on the Intestinal Bacterial Flora of Patients with Diarrhea
Clinical Infectious Diseases, Volume 16, Year 1993
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Description
In the intestinal flora of patients with diarrhea, a close correlation exists between a decrease in numbers of anaerobes and a reduction in levels of short-chain fatty acids. The drastic reduction of intestinal volatile fatty acids (VFAs) accompanying decreased counts of anaerobes during the diarrheal state and the increase in pH thought to arise from these changes result in increased fecal water content. Our data suggest that free bile acids and VFAs may be factors controlling intestinal bacterial populations in vivo, especially in enteric infections. Thus the role of nonspecific factors such as VFAs, which are among the bile acid metabolites produced by anaerobic intestinal bacteria, deserves emphasis in the evaluation of protective mechanisms provided by the intestinal flora against enteric infections. © 1993 by The University of Chicago.
Authors & Co-Authors
Tazume, Seiki
Japan, Isehara
Tokai University School of Medicine
Japan, Sapporo
Hokkaido Institute of Public Health
Kenya, Nairobi
Kenya Medical Research Institute
Ozawa, Atsushi
Japan, Isehara
Tokai University School of Medicine
Japan, Sapporo
Hokkaido Institute of Public Health
Kenya, Nairobi
Kenya Medical Research Institute
Yamamoto, Takako
Japan, Isehara
Tokai University School of Medicine
Japan, Sapporo
Hokkaido Institute of Public Health
Kenya, Nairobi
Kenya Medical Research Institute
Takahashi, Yasuyuki
Japan, Isehara
Tokai University School of Medicine
Japan, Sapporo
Hokkaido Institute of Public Health
Kenya, Nairobi
Kenya Medical Research Institute
Takeshi, Koichi
Japan, Isehara
Tokai University School of Medicine
Japan, Sapporo
Hokkaido Institute of Public Health
Kenya, Nairobi
Kenya Medical Research Institute
Saidi, Suleiman Mzee
Japan, Isehara
Tokai University School of Medicine
Japan, Sapporo
Hokkaido Institute of Public Health
Kenya, Nairobi
Kenya Medical Research Institute
Ichoroh, Catherine G.
Japan, Isehara
Tokai University School of Medicine
Japan, Sapporo
Hokkaido Institute of Public Health
Kenya, Nairobi
Kenya Medical Research Institute
Waiyaki, Peter G.
Japan, Isehara
Tokai University School of Medicine
Japan, Sapporo
Hokkaido Institute of Public Health
Kenya, Nairobi
Kenya Medical Research Institute
Statistics
Citations: 35
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1093/clinids/16.Supplement_2.S77
ISSN:
10584838
e-ISSN:
15376591
Research Areas
Environmental
Infectious Diseases