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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Moving to an A1C-based diagnosis of diabetes has a different impact on prevalence in different ethnic groups
Diabetes Care, Volume 33, No. 3, Year 2010
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Description
OBJECTIVE - To compare screen-detected diabetes prevalence and the degree of diagnostic agreement by ethnicity with the current oral glucose tolerance test (OGTT)-based and newly proposed A1C-based diagnostic criteria. RESEARCH DESIGN AND METHODS - Six studies (1999-2009) from Denmark, the U.K., Australia, Greenland, Kenya, and India were tested for the probability of an A1C ≥6.5% among diabetic case subjects based on an OGTT. The difference in probability between centers was analyzed by logistic regression adjusting for relevant confounders. RESULTS - Diabetes prevalence was lower with the A1C-based diagnostic criteria in four of six studies. The probability of an A1C ≥6.5% among OGTT-diagnosed case subjects ranged widely (17.0-78.0%) by study center. Differences in diagnostic agreement between ethnic subgroups in the U.K. study were of the same magnitude as between-country comparisons. CONCLUSIONS - A shift to an A1C-based diagnosis for diabetes will have substantially different consequences for diabetes prevalence across ethnic groups and populations. © 2010 by the American Diabetes Association.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2827511/bin/supp_33_3_580__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC2827511/bin/supp_dc09-1843_dc09-1843_OnlineOnlyAppendix.pdf
Authors & Co-Authors
Christensen, Dirk Lund
Denmark, Copenhagen
Københavns Universitet
Denmark, Herlev
Steno Diabetes Center Copenhagen
Witte, Daniel R.
Denmark, Herlev
Steno Diabetes Center Copenhagen
Kaduka, L.
Kenya, Nairobi
Kenya Medical Research Institute
Jørgensen, Marit E. Eika
Denmark, Copenhagen
Statens Institut for Folkesundhed
Borch-Johnsen, Knut
Denmark, Herlev
Steno Diabetes Center Copenhagen
Denmark, Glostrup
Amtssygehuset I Glostrup
Mohan, Viswanathan Krishna
Switzerland, Geneva
Organisation Mondiale de la Santé
Shaw, Jonathan E.
Australia, Melbourne
Baker Heart and Diabetes Institute
Tabák, Ádám Gy
United Kingdom, London
University College London
Hungary, Budapest
Semmelweis Egyetem
Vistisen, Dorte
Denmark, Herlev
Steno Diabetes Center Copenhagen
Statistics
Citations: 170
Authors: 9
Affiliations: 9
Identifiers
Doi:
10.2337/dc09-1843
ISSN:
01495992
e-ISSN:
19355548
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Locations
Kenya