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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
CD4 + T-cell count monitoring does not accurately identify HIV-infected adults with virologie failure receiving antiretroviral therapy
Journal of Acquired Immune Deficiency Syndromes, Volume 49, No. 5, Year 2008
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Description
Background: CD4 - T-lymphocyte (CD4) counts are widely used to monitor response to antiretroviral therapy (ART) in resource-limited settings. However, the utility of such monitoring in terms of predicting virologie response to therapy has been little studied. Methods: We studied participants aged 18 years and older who initiated ART in Tororó, Uganda. CD4 counts, CD4 percentages, and viral load (VL) were examined at 6-monthly intervals. Various definitions of immunologic failure were examined to identify individuals with VLs ≥ 50, ≥500, ≥1000, or ≥5000 copies per milliliter at 6, 12, and 18 months after treatment initiation. Results: One thousand sixty-three ART-naive persons initiated ART. The proportion of individuals with virologie failure ranged between 1.5% and 16.4% for each time point. The proportion with no increase in CD4 count from baseline did not differ between those with suppressed or unsuppressed VLs at 6, 18, and 24 months after ART initiation. No increase in CD4 cell counts at 6 months had a sensitivity of 0.04 [95% confidence interval (CI) 0.00 to 0.10] and a positive predictive value of 0.03 (95% CI 0.00 to 0.09) for identifying individuals with VL ≥ 500 copies per milliliter at 6 months. The best measure identified was an absolute CD4 cell count <125 cells per microliter at 21 months for predicting VL ≥ 500 copies per milliliter at 18 months which had a sensitivity of 0.13 (95% CI 0.01 to 0.21) and a positive predictive value of 0.29 (95% CI 0.10 to 0.44). Conclusions: CD4 cell count monitoring does not accurately identify individuals with virologie failure among patients taking ART. Copyright © 2008 Lippincott Williams & Wilkins.
Authors & Co-Authors
Moore, David M.
United States, Atlanta
Centers for Disease Control and Prevention
Canada, Vancouver
British Columbia Centre for Excellence in Hiv-aids
Canada, Vancouver
The University of British Columbia
Awor, Anna Colletar
United States, Atlanta
Centers for Disease Control and Prevention
Downing, Robert G.
United States, Atlanta
Centers for Disease Control and Prevention
Kaplan, Jonathan E.
United States, Atlanta
Centers for Disease Control and Prevention
Montaner, Julio S.G.
Canada, Vancouver
British Columbia Centre for Excellence in Hiv-aids
Canada, Vancouver
The University of British Columbia
Hancock, John
United States, Atlanta
Centers for Disease Control and Prevention
Were, Willy A.
United States, Atlanta
Centers for Disease Control and Prevention
Mermin, Jonathan H.
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 98
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1097/QAI.0b013e318186eb18
ISSN:
15254135
Research Areas
Infectious Diseases
Study Locations
Uganda