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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Combined Role of Troponin and Natriuretic Peptides Measurements in Patients With Covid-19 (from the Cardio-COVID-Italy Multicenter Study)
American Journal of Cardiology, Volume 167, Year 2022
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Description
Data concerning the combined prognostic role of natriuretic peptide (NP) and troponin in patients with COVID-19 are lacking. The aim of the study is to evaluate the combined prognostic value of NPs and troponin in hospitalized COVID-19 patients. From March 1, 2020 to April 9, 2020, consecutive patients with COVID-19 and available data on cardiac biomarkers at admission were recruited. Patients admitted for acute coronary syndrome were excluded. Troponin levels were defined as elevated when greater than the 99th percentile of normal values. NPs were considered elevated if above the limit for ruling in acute heart failure (HF). A total of 341 patients were included in this study, mean age 68 ± 13 years, 72% were men. During a median follow-up period of 14 days, 81 patients (24%) died. In the Cox regression analysis, patients with elevated both NPs and troponin levels had higher risk of death compared with those with normal levels of both (hazard ratio 2.94; 95% confidence interval 1.31 to 6.64; p = 0.009), and this remained significant after adjustment for age, gender, oxygen saturation, HF history, and chronic kidney disease. Interestingly, NPs provided risk stratification also in patients with normal troponin values (hazard ratio 2.86; 95% confidence interval 1.21 to 6.72; p = 0.016 with high NPs levels). These data show the combined prognostic role of troponin and NPs in COVID-19 patients. NPs value may be helpful in identifying patients with a worse prognosis among those with normal troponin values. Further, NPs’ cut-point used for diagnosis of acute HF has a predictive role in patients with COVID-19. © 2021 Elsevier Inc.
Authors & Co-Authors
Iorio, Anna Maria Aria
Italy, Bergamo
Papa Giovanni Xxiii Hospital
Specchia, Claudia
Italy, Brescia
Università Degli Studi Di Brescia
Pozzi, Andrea
Italy, Bergamo
Papa Giovanni Xxiii Hospital
Camporotondo, Rita
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Giovinazzo, Stefano
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Mapelli, Massimo
Italy, Milan
Irccs Centro Cardiologico Monzino
Tomasoni, Daniela
Italy, Brescia
Spedali Civili Di Brescia
Ameri, Pietro
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Gnecchi, Massimiliano
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Leonardi, Sergio
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Agostoni, Piergiuseppe
Italy, Milan
Irccs Centro Cardiologico Monzino
Carugo, Stefano
Italy, Milan
Fondazione Irccs Ca' Granda Ospedale Maggiore Policlinico
Guazzi, Marco
Italy, Milan
Ospedale San Paolo
La Rovere, Maria Teresa
Italy, Pavia
Istituti Clinici Scientifici Maugeri Spa – sb
Mortara, Andrea
Italy, Monza
Policlinico Di Monza
PIEPOLI, MASSIMO Francesco
Italy, Pisa
Sant'anna Scuola Universitaria Superiore Pisa
Porto, Italo
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Volterrani, Maurizio
Italy, Rome
Irccs San Raffaele Pisana
Senni, Michele
Italy, Bergamo
Papa Giovanni Xxiii Hospital
Metra, Marco
Italy, Brescia
Spedali Civili Di Brescia
Statistics
Citations: 12
Authors: 20
Affiliations: 14
Identifiers
Doi:
10.1016/j.amjcard.2021.11.054
ISSN:
00029149
Research Areas
Covid
Environmental
Noncommunicable Diseases
Study Design
Cohort Study
Study Approach
Qualitative
Quantitative
Participants Gender
Male