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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Embryo culture media and IVF/ICSI success rates: A systematic review
Human Reproduction Update, Volume 19, No. 3, Article dms061, Year 2013
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Description
Background: The media that are used to culture human preimplantation embryos are considered to be an important factor for the success rates of IVF/ICSI. Here, we present a systematic review of randomized controlled trials (RCTs) on the effect of culture media on IVF/ICSI success rates. Methods: RCTs published between January 1985 and July 2012 were eligible for inclusion. The primary outcome was live birth. Secondary outcomes were health of babies born, ongoing pregnancies, clinical pregnancies, miscarriages, multiple pregnancies, implantation rate, cryopreservation rate, embryo quality and fertilization rate. For those media that were evaluated in more than one comparison, an unconventional meta-analysis was performed by pooling the data of the media they were compared to. Results: Twenty-two RCTs were included that evaluated 31 different comparisons. Conventional meta-analysis was not possible for any of the outcomes as nearly all trials compared different culture media. Only four trials reported on live birth, and one of them reported a significant difference. Nine trials reported on ongoing and/or clinical pregnancy rates, of which four showed a significant difference. Pooling the data did not reveal a superior culture medium. Conclusions: It is yet unknown what culture medium leads to the best success rates in IVF/ICSI. Given the potential importance of culture media for treatment outcome, rigorously designed RCTs are needed for currently available, as well as newly introduced culture media. © The Author 2013. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology.
Authors & Co-Authors
Mantikou, E.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Youssef, M. A.F.M.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Egypt, Cairo
Faculty of Medicine
Egypt, Cairo
Egyptian International Fertility Center-ivf Eifc-ivf
Van Wely, Madelon
Netherlands, Amsterdam
Universiteit Van Amsterdam
van der Veen, Fulco V.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Al-Inany, Hesham Gaber
Egypt, Cairo
Faculty of Medicine
Repping, Sjoerd R.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Mastenbroek, S.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Statistics
Citations: 128
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1093/humupd/dms061
ISSN:
13554786
e-ISSN:
14602369
Research Areas
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Study Approach
Systematic review