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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Geographic variation in infant loss of maternal measles antibody and in prevalence of rubella antibody
American Journal of Epidemiology, Volume 124, No. 3, Year 1986
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Description
Maternal and cord measles and rubella antibodies were compared in 15 populations from Brazil, Ecuador, Chile, India, Jordan, Nigeria, South Africa, Taiwan, and the United States. Review of the literature concerning these countries showed that a higher proportion of children 6-12 months of age responded immunologically to measles vaccine in areas with low per capita product than in wealthier populations. The authors show that this difference reflects differences in maternal antibody titer and differences in efficiency of transport of measles immunity across the placenta. No variation in the half-life of passive measles immunity in the infant was found in comparing three geographic areas. When these biologic factors are fully evaluated, it should be possible to predict the response to be expected from vaccination at any particular age without directly testing the vaccine in children below and above generally recommended ages for vaccination. With regard to rubella, high antibody prevalence rates were found in most of the developing countries, as well as in the United States, and these countries are therefore unlikely to encounter widespread problems with congenital rubella. However, Taiwan, and all of four areas of Brazil have prevalence rates which are no higher than those which pertained in the United States prior to establishment of the rubella immunization program. The authors believe that protection of the infants in these countries is a matter of high priority, but that, if approached hastily, it could exacerbate the problem. © 1986 by The Johns Hopkins University School of Hygiene and Public Health.
Authors & Co-Authors
Black, F. L.
United States, New Haven
Yale School of Medicine
Berman, L. L.
United States, New Haven
Yale School of Medicine
Borgoño, J. M.
Brazil
Ministerio de Salud
Capper, R. A.
United States, New Haven
Yale School of Medicine
Carvalho, A. A.
Brazil, Sao Paulo
Universidade Federal de São Paulo
Collins, C.
United States, New Haven
Yale School of Medicine
Glover, O.
Nigeria, Lagos
Supramedics Laboratory
Hijazi, Z.
United States, New Haven
Yale School of Medicine
Jacobson, D. L.
United States, New Haven
Yale School of Medicine
Lee, Y. L.
United States, Irvine
University of California, Irvine
Libel, M.
Brazil, Porto Alegre
Secretaria de Saude e do Meio Ambiente
Linhares, Alexandre Da Costa
Brazil, Ananindeua
Instituto Evandro Chagas
Mendizabal-morris, C. A.
United States, El Paso
Pan American Health Organization
Simoẽs, Eric A.F.
India, Vellore
Christian Medical College, Vellore
Siqueira-campos, E.
Unknown Affiliation
Stevenson, J.
United States, New Haven
Yale School of Medicine
Vecchi, N.
United States, New Haven
Yale School of Medicine
Statistics
Citations: 96
Authors: 17
Affiliations: 9
Identifiers
Doi:
10.1093/oxfordjournals.aje.a114415
ISSN:
00029262
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Nigeria
South Africa