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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Helicobacter pylori serologic status has no influence on the association between fucosyltransferase 2 polymorphism (FUT2 461 G→A) and vitamin B-12 in Europe and West Africa
American Journal of Clinical Nutrition, Volume 95, No. 2, Year 2012
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Description
Background: Genomewide association studies have shown a relation between plasma vitamin B-12 concentration and the 461G→A polymorphism of fucosyltransferase 2 (FUT2), a gene associated with susceptibility to Helicobacter pylori infection. Objective: We evaluated in 2 populations the association of FUT2 461 G→A polymorphism with vitamin B-12 and related metabolic markers and investigated whether the influence of FUT2 on H. pylori serology is part of the mechanisms that underlie these associations. Design: The study included 1282 ambulatory subjects from Europe and West Africa. Blood concentrations of vitamin B-12, folate, homocysteine, and methylmalonic acid were measured. Genotyping was performed by real-time polymerase chain reaction. H. pylori serology testing was performed by using ELISA. Results: In univariate analysis, FUT2 461 A/A genotype was associated with higher plasma vitamin B-12 concentration in the total population (P = 0.0007) as well as in Europe (P = 0.0009) and in West Africa (P = 0.0015). Positivity for H. pylori serology was higher in West Africa (P < 0.0001) and was not associated with low plasma vitamin B-12. The prevalence of H. pylori-positive patients did not differ among FUT2 461 G→A genotypes (P = 0.2068). In multivariate analysis, FUT2 461 G→A genotype (P = 0.0008), but not positive H. pylori serology, was an independent predictor of plasma vitamin B-12 concentration. Conclusion: This study confirms the influence of FUT2 461 G→A polymorphism on plasma vitamin B-12 concentration and showed no influence of H. pylori serologic status on this association in ambulatory subjects from Europe and West Africa. © 2012 American Society for Nutrition.
Authors & Co-Authors
Oussalah, Abderrahim
France, Nancy
Université de Lorraine
Besseau, Cyril
France, Nancy
Université de Lorraine
Chéry, Céline
France, Nancy
Université de Lorraine
Jeannesson, Élise
France, Nancy
Université de Lorraine
Guéant-Rodríguez, Rosa María
France, Nancy
Université de Lorraine
Anello, Guido
Italy, Troina
Oasi Research Institute-irccs
Bosco, Paolo
Italy, Troina
Oasi Research Institute-irccs
Elia, Maurizio
Italy, Troina
Oasi Research Institute-irccs
Romano, Antonino G.
Italy, Troina
Oasi Research Institute-irccs
Italy, Rome
Università Cattolica Del Sacro Cuore, Campus Di Roma
Bronowicki, Jean Pierre
France, Nancy
Université de Lorraine
Gérard, Philippe
France, Nancy
Université de Lorraine
Paoli, Justine
France, Nancy
Université de Lorraine
Avogbe, Patrice Hodonou
France, Nancy
Université de Lorraine
Chabi, Nicodème W.
Benin, Cotonou
Université de Cotonou
Sanni, Ambaliou
Benin, Cotonou
Université de Cotonou
Amouzou, Emile Kou Santa Sabiba
Togo, Lome
Laboratory of Biochemistry and Nutrition
Peyrin-Biroulet, Laurent
France, Nancy
Université de Lorraine
Gueánt, Jean Louis
France, Nancy
Université de Lorraine
Italy, Troina
Oasi Research Institute-irccs
Statistics
Citations: 21
Authors: 18
Affiliations: 5
Identifiers
Doi:
10.3945/ajcn.111.016410
ISSN:
00029165
e-ISSN:
19383207
Research Areas
Food Security
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Locations
Multi-countries