Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Genetic variation in Tunisia in the context of human diversity worldwide
American Journal of Physical Anthropology, Volume 161, No. 1, Year 2016
Notification
URL copied to clipboard!
Description
Objectives: North Africa has a complex demographic history of migrations from within Africa, Europe, and the Middle East. However, population genetic studies, especially for autosomal genetic markers, are few relative to other world regions. We examined autosomal markers for eight Tunisian and Libyan populations in order to place them in a global context. Materials and Methods: Data were collected by TaqMan on 399 autosomal single nucleotide polymorphisms on 331 individuals from Tunisia and Libya. These data were combined with data on the same SNPs previously typed on 2585 individuals from 57 populations from around the world. Where meaningful, close by SNPs were combined into multiallelic haplotypes. Data were evaluated by clustering, principal components, and population tree analyses. For a subset of 102 SNPs, data from the literature on seven additional North African populations were included in analyses. Results: Average heterozygosity of the North African populations is high relative to our global samples, consistent with a complex demographic history. The Tunisian and Libyan samples form a discrete cluster in the global and regional views and can be separated from sub-Sahara, Middle East, and Europe. Within Tunisia the Nebeur and Smar are outlier groups. Across North Africa, pervasive East-West geographical patterns were not found. Discussion: Known historical migrations and invasions did not displace or homogenize the genetic variation in the region but rather enriched it. Even a small region like Tunisia contains considerable genetic diversity. Future studies across North Africa have the potential to increase our understanding of the historical demographic factors influencing the region. Am J Phys Anthropol 161:62–71, 2016. © 2016 The Authors American Journal of Physical Anthropology Published by Wiley Periodicals, Inc.
Authors & Co-Authors
Cherni, L.
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Tunisia, Monastir
Institut Supérieur de Biotechnologie de Monastir
Pakstis, Andrew J.
United States, New Haven
Yale School of Medicine
Boussetta, Sami
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Elkamel, Sarra
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Frigi, Sabeh
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Khodjet-El-Khil, H.
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Barton, Alison
United States, New Haven
Yale School of Medicine
Haigh, Eva
United States, New Haven
Yale School of Medicine
Speed, William C.
United States, New Haven
Yale School of Medicine
Ben Ammar Elgaaied, Amel
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Kidd, Judith R.
United States, New Haven
Yale School of Medicine
Kidd, Kenneth K.
United States, New Haven
Yale School of Medicine
Statistics
Citations: 38
Authors: 12
Affiliations: 3
Identifiers
Doi:
10.1002/ajpa.23008
ISSN:
00029483
e-ISSN:
10968644
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Multi-countries
Libya
Tunisia