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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic
International Journal of Nanomedicine, Volume 9, No. 1, Year 2014
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Description
This study describes the preparation, characterization, and controlled release of a streptomycin-chitosan-magnetic nanoparticle-based antibiotic in an effort to improve the treatment of bacterial infections. Specifically, chitosan-magnetic nanoparticles were synthesized by an incorporation method and were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, and vibrating sample magnetometry. Streptomycin was incorporated into the nanoparticles to form a streptomycin-coated chitosan-magnetic nanoparticle (Strep-CS-MNP) nanocomposite. The release profiles showed an initially fast release, which became slower as time progressed. The percentage of drug released after 350 minutes was around 100%, and the best fit mathematical model for drug release was the pseudo-second order model. The Strep-CS-MNP nanocomposite showed enhanced antibacterial activity against methicillin-resistant Staphylococcus aureus. This study forms a significant basis for further investigation of the Strep-CS-MNP nanocomposite in the treatment of various bacterial infections. © 2014 Hussein-Al-Ali et al.
Authors & Co-Authors
Hussein-Al-Ali, Samer Hasan
Malaysia, Serdang
Universiti Putra Malaysia
El Zowalaty, Mohamed Ezzat
Malaysia, Serdang
Universiti Putra Malaysia
Saudi Arabia, Jazan
Jazan University
Hussein, M. Z.B.
Malaysia, Serdang
Universiti Putra Malaysia
Ismail, Maznah
Malaysia, Serdang
Universiti Putra Malaysia
Webster, Thomas Jay
United States, Boston
Northeastern University
Saudi Arabia, Jeddah
King Abdulaziz University
Statistics
Citations: 68
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.2147/IJN.S53079
ISSN:
11769114
e-ISSN:
11782013