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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Fibrosis progression in paired liver biopsies from HIV/HCV co-infected patients
Hepatitis Monthly, Volume 11, No. 7, Year 2011
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Description
Background: Chronic hepatitis C is more aggressive during HIV infection. Available data about risk factors of liver fibrosis in HIV/HCV co-infected patients derive from studies based on a single liver biopsy. Objectives: To evaluate the risk factors of liver fibrosis progression (LFP) and to investigate the role of antiretroviral therapy (ARV) in HIV/HCV patients who underwent paired liver biopsy. Patients and Methods: We retrospectively studied 58 patients followed at two Infectious Diseases Departments in Northern Italy during the period 1988-2005. All specimens were double-blinded and centrally examined by two pathologists. LFP was defined when an increase of at least one stage occurred in the second biopsy, according to the Ishak-Knodell classification. Results: In a univariate analysis, serum levels of alanine aminotransferase (ALT) > 150 IU/L at the first biopsy (P = 0.02), and a > 20% decrease in CD4+ cell count between the two biopsies (P = 0.007), were significantly associated with LFP. In multivariate analysis, a > 20% decrease in CD4+ cell count remained independently associated to LFP (odds ratio, 3.99; 95% confidence interval, 1.25-12.76; P < 0.02). Analysis of life survival curves confirmed the correlation between CD4+ cell count and LFP. Conclusions: Our findings highlight that in HIV/HCV coinfected patients, an effective antiretroviral therapy that assures a good immune-virological profile contributes to reducing the risk of LFP. © 2011 Kowsar M.P.Co.
Authors & Co-Authors
Zerbi, Pietro
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Sagnelli, C.
Italy, Milan
Irccs Ospedale San Raffaele
Vago, Gianluca Luca
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Giorgi, Ricardo Rodrigues
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Rizzardini, Giuliano
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Gubertini, Guido A.
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Statistics
Citations: 15
Authors: 6
Affiliations: 3
Identifiers
ISSN:
1735143X
Research Areas
Infectious Diseases
Study Design
Case-Control Study