Serum chemerin correlated to the SYNTAX score in obese Egyptian patients with coronary artery disease

Background: Chemerin is a newly discovered adipokine which has been found closely associated with obesity, metabolic syndrome, and infl ammatory status. However, it remains unclear whether chemerin is involved in patients with cardiovascular disease. Objective: The aim of the study was to examine whether serum chemerin levels are associated with the severity of coronary artery disease (CAD) in obese Egyptian patients. Material and methods: The study enrolled 100 patients who underwent coronary angiography for clinically indicated reasons classifi ed according to body mass index (BMI) into two groups, 50 patients (group A) with BMI (≥30 kg/m2) and 50 patients (group B) with BMI ≤25 kg/m2. Severity of CAD was estimated with SYNTAX score and serum chemerin level was measured using ELISA method. Results: Serum chemerin level was higher in obese patients (p = 0.019), and it was positively correlated with SYNTAX score (r = 0.533, p <0.001), BMI, waist circumference, FPG, left ventricle mass index (LVMI) and high sensitivity C-reactive protein (hs-CRP) (p value <0.005 for all). Serum chemerin levels were signifi cantly increased with an increasing number of diseased vessels (p = 0.013). At multiple linear regression analysis serum chemerin level was found to be an independent predictor of SYNTAX score (b = 0.432, p <0.001). Serum chemerin also was associated with LVH (p = 0.004) Conclusion: Serum chemerin levels were higher in obese patients and were associated with LVH and infl ammation. Also it has a signifi cant correlation with severity of coronary artery disease in Egyptian patients with coronary artery disease.