Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Arginine 16 glycine polymorphism in β 2-adrenergic receptor gene is associated with obesity, hyperlipidemia, hyperleptinemia, and insulin resistance in saudis
International Journal of Endocrinology, Volume 2012, Article 945608, Year 2012
Notification
URL copied to clipboard!
Description
Background. Several studies have shown an association between codon 16 polymorphism of the β2AR gene and obesity. Methods. We studied the association between Arg16Gly polymorphism and obesity and its influence on anthropometric parameters, lipids, insulin resistance and leptin in Saudi individuals. The study group included 329 individuals (males: 109 and females: 220). Metabolic parameters, including glucose, lipids, insulin, and leptin were analyzed and anthropometric parameters including waist and hip circumference, waist/hip (W/H) ratio, and body mass index (BMI) were measured and HOMA-IR was calculated. Genotyping was conducted by DNA sequencing of 353 bp fragments, carrying the Arg16Gly polymorphic site. Results and Conclusion. Overweight and obese subjects had a significantly higher frequency of Gly16 (0.375 and 0.38, resp.) compared with normal-weight subjects (0.200). In addition, subjects carrying Gly16 allele regardless of their BMI had greater waist and hip circumference, W/H ratio, plasma lipids, leptin, glucose level, and insulin resistance as judged from the HOMA-IR, compared to those with the wild-type allele. The findings of this study show a significant association between the Arg16Gly polymorphism in β2AR gene and the development of insulin resistance, overweight, and obesity in Saudi populations with an influence on the levels of lipid and leptin. © 2012 Maha H. Daghestani et al.
Authors & Co-Authors
Daghestani, Maha Hasan
Saudi Arabia, Riyadh
King Saud University
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Warsy, Arjumand Sultan
Saudi Arabia, Riyadh
King Saud University
Daghestani, Mazin
Saudi Arabia, Makkah
Umm Al-qura University
Al-Odaib, Ali Nasser
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
ElDali, Abdelmoneim M.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Al-Eisa, Nadia A.
Saudi Arabia, Riyadh
King Saud University
Omer, S. A.
Saudi Arabia, Riyadh
King Saud University
Hassan, Zeinab Korany
Saudi Arabia, Riyadh
King Saud University
Statistics
Citations: 20
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1155/2012/945608
ISSN:
16878337
e-ISSN:
16878345
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Participants Gender
Female