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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Marked independent relationship between circulating interleukin-6 concentrations and endothelial activation in rheumatoid arthritis
Mediators of Inflammation, Volume 2013, Article 510243, Year 2013
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Description
We examined the potential impact of conventional compared with nonconventional cardiovascular risk factors including interleukin-6 levels on endothelial activation in RA. Circulating soluble E-selectin, vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 concentrations were measured in 217 African patients (112 black and 105 white) with RA. In comprehensive confounder adjusted mixed regression models, 5 conventional and 4 nonconventional cardiovascular risk factors were associated (P = 0.05 to <0.0001) with endothelial activation. Interleukin-6 was the only risk factor related to each endothelial activation molecule and independently contributed by 18% and significantly more than other risk factors to the variation in overall endothelial activation as estimated by an SD (z) score of endothelial activation molecule concentrations. The independent interleukin-6-overall endothelial activation relationships were reproduced in various subgroups. Interleukin-6 concentrations relate consistently, markedly, and to a larger extent than other cardiovascular risk factors to endothelial activation in RA. Assessment of interleukin-6 concentrations may enhance cardiovascular risk stratification in RA. © 2013 Patrick H. Dessein et al.
Authors & Co-Authors
Dessein, Patrick Hector M.C.
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
Solomon, Ahmed
South Africa, Johannesburg
University of the Witwatersrand
Woodiwiss, Angela Jill
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
Norton, Gavin R.
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
Tsang, Linda
South Africa, Johannesburg
Milpark Hospital
González-Gay, Miguel Ángel
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Statistics
Citations: 30
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1155/2013/510243
ISSN:
09629351
e-ISSN:
14661861
Research Areas
Noncommunicable Diseases