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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Nasal carriage of mycobactrium leprae DNA in health individuals in Lega Robi village, Ethiopia
Ethiopian Medical Journal, Volume 42, No. SUPPL. 1, Year 2004
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Description
The number of registered leprosy patients world-wide has decreased dramatically after extensive application of WHO recommended Multiple Drug Therapy (MDT). The annual number of new cases has, however, been almost unchanged in several populations, indicating that the infection is still present at community level. Nasal carriage of Mycobacterium leprae DNA was studied in Lega Robi village in Ethiopia. MDT had been applied for more than ten years, and 718 residents over 5 years old were eligible for the study. During the first survey nasal swab samples were collected from 664 (92.5%) individuals. The results of a Peptide Nucleic Acid-ELISA test for M. leprae DNA interpreted by stringent statistical criteria were available for 589 (88.7%) subjects. Thirty-five (5.9%) individuals without clinical signs of leprosy were positive for M. leprae DNA. Seven PCR positive individuals lived in a household where one or two other members were also positive for M. leprae DNA. During a second survey 8 (4.6%) of 175 interpretable PNA-ELISA tests were positive. Of 137 individuals tested twice, only two were positive on both occasions whereas 10 were PCR positive only once. The study confirms the widespread distribution of M. leprae DNA in healthy individuals. The feasibility of curbing possible transmission of subclinical infection needs further consideration. ©2003 Cambrige University Press.
Authors & Co-Authors
Beyene, Demissew
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Aseffa, Abraham
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Harboe, Morten H.
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Norway, Oslo
Rikshospitalet-radiumhospitalet hf
Kidane, Dawit
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Macdonald, M.
United Kingdom, London
Ucl Institute of Ophthalmology
Klatser, Paul R.
Netherlands, Amsterdam
Royal Tropical Institute - Kit
Bjune, Gunnar Aksel
Norway, Oslo
Universitetet I Oslo
Smith, William Cairns S.
United Kingdom, Aberdeen
University of Aberdeen
Statistics
Citations: 42
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1017/S0950268803001079
ISSN:
00141755
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Ethiopia