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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Luminal B tumors are the most frequent molecular subtype in breast cancer of North African women: An immunohistochemical profile study from Morocco
Diagnostic Pathology, Volume 7, No. 1, Article 170, Year 2012
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Description
Background: Breast cancer may be classified into luminal A, luminal B, HER2+/ER-, basal-like and normal-like subtypes based on gene expression profiling or immunohistochemical (IHC) characteristics. The aim of our study is to show the molecular profile characteristic of breast cancer in the North African population of Morocco. This work showed preliminary results and correlations with clinicopathological and histological parameters. Three hundred and ninety primary breast carcinomas tumor tissues were immunostained for ER, PR, HER2, CK5/6, CK8/18 and Ki67 using paraffin tissue.Methods: We reviewed 390 cases of breast cancer diagnosed on January 2008 to December 2011 at the Department of pathology, Hassan II teaching hospital, Fez, Morocco. Age, size tumor, metastatic profile, node involvement profile, histological type and immunohistochemical profile were studied.Results: The average age was 46 years; our patients were diagnosed late with a high average tumor size. Luminal B subtype was more prevalent (41.8%), followed by luminal A (30.5%), basal-like (13, 6%), Her2-overexpressing (9, 2%), and unclassified subtype (4.9%).Conclusion: This study showed that molecular classification and biological profile may be different according to geographical distribution, to encourage further studies to know the genomic profile of tumors and the environment.Virtual slide: http://www.diagnosticpathology.diagnomx.eu/vs/1675272504826544. © 2012 EL FATEMI; licensee BioMed Central Ltd.
Authors & Co-Authors
El-Fatemi, Hinde
Morocco, Fez
Centre Hospitalier Universitaire Hassan Ii
Chahbouni, Sanae
Morocco, Fez
Centre Hospitalier Universitaire Hassan Ii
Jayi, Sofia
Morocco, Fez
Centre Hospitalier Universitaire Hassan Ii
Moumna, Kaoutar
Morocco, Fez
Centre Hospitalier Universitaire Hassan Ii
Melhouf, Moulay Abdelilah
Morocco, Fez
Centre Hospitalier Universitaire Hassan Ii
Banani, Abdelaziz
Morocco, Fez
Centre Hospitalier Universitaire Hassan Ii
Mesbahi, Omar
Morocco, Fez
Centre Hospitalier Universitaire Hassan Ii
Amarti, Afaf R.
Morocco, Fez
Centre Hospitalier Universitaire Hassan Ii
Statistics
Citations: 35
Authors: 8
Affiliations: 1
Identifiers
Doi:
10.1186/1746-1596-7-170
e-ISSN:
17461596
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Study Design
Cross Sectional Study
Study Locations
Morocco
Participants Gender
Female