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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, induces the production of anti-inflammatory cyclodepsipeptides from Beauveria felina
Journal of Natural Products, Volume 76, No. 7, Year 2013
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Description
The addition of the histone deacetylase inhibitor suberoylanilide hydroxamic acid to a culture of the filamentous fungus Beauveria felina significantly changed its secondary metabolite profile and led to the isolation of eight compounds, including three new cyclodepsipeptides, desmethylisaridin E (1), desmethylisaridin C2 (2), and isaridin F (3), along with five known cyclodepsipeptide compounds. Isaridin F (3) possesses a cyclodepsipeptide ring with N-methylbutyric acid, which is rare in natural peptides. Absolute configurations of the new cyclodepsipeptides were achieved by Marfey's method. The anti-inflammatory activity of the isolated compounds was investigated through evaluating their effect on superoxide anion production and elastase release by FMLP-induced human neutrophils. Among the tested compounds, desmethylisaridin E (1) inhibited superoxide anion production and desmethylisaridin C2 (2) inhibited elastase release, with IC50 values of 10.00 ± 0.80 and 10.01 ± 0.46 μM, respectively. © 2013 The American Chemical Society and American Society of Pharmacognosy.
Authors & Co-Authors
Chung, Yuming
Taiwan, Kaohsiung
Kaohsiung Medical University
El-Shazly, Mohamed
Taiwan, Kaohsiung
Kaohsiung Medical University
Egypt, Cairo
Faculty of Pharmacy - Ain Shams University
Chuang, Dawei
Taiwan, Kaohsiung
Kaohsiung Medical University
Hwang, Tsong Long
Taiwan, Taoyuan
Chang Gung University College of Medicine
Asai, Teigo
Japan, Sendai
Tohoku University
Oshima, Yoshiteru
Japan, Sendai
Tohoku University
Ashour, Mohamed Lotfy
Egypt, Cairo
Faculty of Pharmacy - Ain Shams University
Wu, Yangchang
Taiwan, Kaohsiung
Kaohsiung Medical University
Taiwan, Taichung
China Medical University
Taiwan, Taichung
China Medical University Hospital
Chang, Fangrong
Taiwan, Kaohsiung
Kaohsiung Medical University
Statistics
Citations: 53
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1021/np400143j
ISSN:
01633864
e-ISSN:
15206025