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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Alcohol consumption and neurocognitive deficits in people with well-treated HIV in Switzerland
PLoS ONE, Volume 16, No. 3 March, Article e0246579, Year 2021
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Description
Background Hazardous alcohol consumption and HIV infection increase the risk of neurocognitive impairment (NCI). We examined the association between alcohol consumption and specific neurocognitive domain function in people with HIV (PWH) taking modern antiretroviral therapy. Methods The Neurocognitive Assessment in the Metabolic and Aging Cohort (NAMACO) study is a prospective, longitudinal, multicentre and multilingual (French, German and Italian) study of patients aged ≥45 years old enrolled in the Swiss HIV Cohort Study (SHCS). Baseline data from 981 study participants were examined. Five neurocognitive domains were evaluated: motor skills, speed of information processing, attention/working memory, executive function and verbal episodic memory. NCI was examined as binary (presence/absence) and continuous (mean z-score) outcomes against Alcohol Use Disorders Identification Test for Consumption (AUDIT-C) scores using logistic and linear regression models, respectively. Results Most participants (96.2%) had undetectable viral loads and 64% were aged >50 years old. Hazardous alcohol consumption was observed in 49.4% of participants and binge drinking in 4.2%. While alcohol consumption frequency and quantity were not associated with NCI, the practice of binge drinking was significantly associated with impaired motor skills and overall neurocognitive function in both binary (odds ratio, OR ≥2.0, P <0.05) and continuous (mean z-score difference -0.2 to -0.4, P ≤0.01) outcomes. A significant U-shaped distribution of AUDIT-C score was also observed for motor skills and overall neurocognitive function. Conclusions In this cohort of PWH with well-controlled HIV infection, NCI was associated with the practice of binge drinking rather than alcohol consumption frequency or quantity. Longitudinal analysis of alcohol consumption and NCI in this population is currently underway. Copyright: © 2021 Darling et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Authors & Co-Authors
Darling, Katharine Elizabeth Anna
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Locatelli, Isabella
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Brugger, Peter
Switzerland, Zurich
Universitatsspital Zurich
Hasse, Barbara Katharina
Switzerland, Zurich
Universität Zürich
Kovari, Helen
Switzerland, Zurich
Universität Zürich
Stoeckle, Marcel P.
Switzerland, Basel
Universitat Basel
Schmid, Patrick
Switzerland, St Gallen
Kantonsspital St.gallen
Tarr, Philip E.
Switzerland, Basel
Universitat Basel
Daeppen, Jean Bernard
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Cavassini, Matthias
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Derfuss, Tobias J.
Unknown Affiliation
Jelčić, Ilijas
Unknown Affiliation
Doco-Lecompte, Thanh
Unknown Affiliation
Bernasconi, Enos
Unknown Affiliation
Scherrer, Alexandra U.
Unknown Affiliation
Décosterd, Laurent Arthur
Unknown Affiliation
Vargas, Maria Isabel
Unknown Affiliation
Aebi-Popp, Karoline
Unknown Affiliation
Anagnostopoulos, Alexia
Unknown Affiliation
Battegay, Manuel
Unknown Affiliation
Böni, Jürg
Unknown Affiliation
Braun, Dominique Laurent
Unknown Affiliation
Bucher, Heíner C.C.
Unknown Affiliation
Ciuffi, Angela
Unknown Affiliation
Dollenmaier, Guenter
Unknown Affiliation
Egger, Matthias
Unknown Affiliation
Elzi, Luigia
Unknown Affiliation
Fehr, Jan Sven
Unknown Affiliation
Fellay, Jacques
Unknown Affiliation
Furrer, Hansjakob Jackob
Unknown Affiliation
Günthard, Huldrych F.
Unknown Affiliation
Haerry, David Hans Ulrich
Unknown Affiliation
Hirsch, Hans H.
Unknown Affiliation
Hoffmann, Matthias
Unknown Affiliation
Hösli, Irene Mathilde
Unknown Affiliation
Huber, Michael J.
Unknown Affiliation
Kahlert, Christian R.
Unknown Affiliation
Kaiser, Laurent K.
Unknown Affiliation
Keiser, Olivia
Unknown Affiliation
Klimkait, Thomas
Unknown Affiliation
Kouyos, Roger D.
Unknown Affiliation
Ledergerber, Bruno
Unknown Affiliation
Martinez de Tejada, Begoña
Unknown Affiliation
Marzolini, Catia
Unknown Affiliation
Metzner, Karin Jutta
Unknown Affiliation
Müller, Nicolas J.
Unknown Affiliation
Nicca, Dunja
Unknown Affiliation
Paioni, Paolo
Unknown Affiliation
Pantaleo, Giuseppe P.
Unknown Affiliation
Perreau, Matthieu
Unknown Affiliation
Rauch, Andri
Unknown Affiliation
Rudin, Christoph
Unknown Affiliation
Speck, Roberto F.
Unknown Affiliation
Stöckle, Marcel
Unknown Affiliation
Trkola, Alexandra
Unknown Affiliation
Vernazza, Pietro Luigi
Unknown Affiliation
Wandeler, Gilles
Unknown Affiliation
Yerly, Sabine T.B.D.
Unknown Affiliation
Statistics
Citations: 2
Authors: 58
Affiliations: 11
Identifiers
Doi:
10.1371/journal.pone.0246579
ISSN:
19326203
Research Areas
Health System And Policy
Infectious Diseases
Mental Health
Noncommunicable Diseases
Substance Abuse
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Study Approach
Quantitative