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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Totally implantable central venous access port infections in patients with digestive cancer: Incidence and risk factors
American Journal of Infection Control, Volume 40, No. 10, Year 2012
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Description
Background: Central venous access port-related bloodstream infection (CVAP-BSI) is associated with morbidity and mortality in patients with cancer. This study examined the incidence rates and risk factors for CVAP-BSI in adult patients with digestive cancer. Methods: This prospective observational cohort study was performed from 2007 to 2011 in 2 oncology units of a university hospital. Incidence rate was expressed as number of CVAP-BSI per 1,000 catheter-days. A Cox regression model was used to identify risk factors for CVAP-BSI. Results: A total of 315 patients were included. CVAP-BSI occurred in 41 patients (13.0%). The overall incidence rate was 0.76/1,000 catheter-days. The rate was higher in patients with esophageal cancer (1.28. P =.05) and pancreatic cancer (1.24; P =.007). Risk factors independently associated with CVAP-BSI were World Health Organization performance status between 2 and 4, catheter utilization-days in the previous month, pancreatic cancer, and parenteral nutrition. Coagulase-negative Staphylococci and enterobacteria were the main microorganisms isolated. Conclusions: In adult patients with digestive cancer, pancreatic cancer, cumulative catheter utilization-days, World Health Organization performance status, and parenteral nutrition were identified as independent risk factors for CVAP-BSI. Patients with any of these risk factors could be candidates for preventive strategies. Copyright © 2012 by the Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.
Authors & Co-Authors
Touré, Abdoulaye
France, Saint-genes-champanelle
Centre Clermont-auvergne-rhône-alpes
France, Lyon
Chu de Lyon
Vanhems, Philippe V.
France, Lyon
Chu de Lyon
France, Villeurbanne
Laboratoire de Biométrie et Biologie Évolutive
Lombard-Bohas, Catheríne H.
France, Lyon
Chu de Lyon
Cassier, Philippe Alexandre
France, Lyon
Chu de Lyon
Écochard, René
France, Lyon
Chu de Lyon
Chambrier, Cécile
France, Saint-genes-champanelle
Centre Clermont-auvergne-rhône-alpes
France, Lyon
Chu de Lyon
Statistics
Citations: 39
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/j.ajic.2012.01.024
ISSN:
15273296
Research Areas
Cancer
Food Security
Health System And Policy
Study Design
Cohort Study
Study Approach
Quantitative