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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Increased dopaminergic neurotransmission in therapy-naïve asymptomatic HIV patients is not associated with adaptive changes at the dopaminergic synapses
Journal of Neural Transmission, Volume 117, No. 6, Year 2010
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Description
Central dopaminergic (DA) systems are affected during human immunodeficiency virus (HIV) infection. So far, it is believed that they degenerate with progression of HIV disease because deterioration of DA systems is evident in advanced stages of infection. In this manuscript we found that (a) DA levels are increased and DA turnover is decreased in CSF of therapy-naïve HIV patients in asymptomatic infection, (b) DA increase does not modulate the availability of DA transporters and D2-receptors, (c) DA correlates inversely with CD4+ numbers in blood. These findings show activation of central DA systems without development of adaptive responses at DA synapses in asymptomatic HIV infection. It is probable that DA deterioration in advanced stages of HIV infection may derive from increased DA availability in early infection, resulting in DA neurotoxicity. Our findings provide a clue to the synergism between DA medication or drugs of abuse and HIV infection to exacerbate and accelerate HIV neuropsychiatric disease, a central issue in the neurobiology of HIV. © 2010 Springer-Verlag.
Authors & Co-Authors
Scheller, Carsten
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Arendt, Gabriele
Germany, Dusseldorf
Universitätsklinikum Düsseldorf
Nolting, Thorsten
Germany, Dusseldorf
Universitätsklinikum Düsseldorf
Antke, C.
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Sopper, Sieghart
Germany, Gottingen
Deutsches Primatenzentrum
Maschke, Matthias
Germany, Essen
Universitätsklinikum Essen
Obermann, Mark
Germany, Essen
Universitätsklinikum Essen
Angerer, A.
Germany, Essen
Universitätsklinikum Essen
Husstedt, Ingo Wilhelm
Germany, Munster
Universitätsklinikum Münster
Meisner, F.
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Neuen-Jacob, E.
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Müller, H. W.
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Carey, Paul D.
South Africa, Stellenbosch
Stellenbosch University
ter Meulen, V.
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Riederer, Peter Franz
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Koutsilieri, Eleni
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Statistics
Citations: 54
Authors: 16
Affiliations: 7
Identifiers
Doi:
10.1007/s00702-010-0415-6
ISSN:
03009564
e-ISSN:
14351463
Research Areas
Infectious Diseases