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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
TP53 codon 72 polymorphism and risk of conjunctival squamous cell carcinoma in Uganda
Cancer Detection and Prevention, Volume 29, No. 6, Year 2005
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Description
Background: The most common TP53 gene polymorphism, which alters the amino acid sequence of the oncosuppressor p53 protein, is located at the codon 72, resulting in either Pro72 or Arg72 p53 variant. Several studies have associated this polymorphism with different types of cancer. We have analyzed the distribution and the role of TP53 Arg72 and Pro72 alleles in conjunctival neoplasia. Method: The study included 41 invasive conjunctival squamous cell carcinoma (ICSCC), 33 conjunctival intraepithelial neoplasia of grade 3 (CIN3), 33 of moderate grade (CIN1 and CIN2), and 115 controls from Uganda, a sub-Saharan country with the highest incidence rate of conjunctival neoplasia in the World, particularly in the era of AIDS. The TP53 Arg/Arg codon 72 genotype was detected in 21.9% of ICSCC and in 18.2% of CIN3 but only in 6% of CIN1-2 and in 5.2% of controls (P < 0.05). Results: These data show an increased risk of ICSCC (odds ratio (OR) = 6.2, 95% confidence interval (CI): 1.6-24.6) and CIN3 (OR = 4.1, 95% CI: 1.0-18.0) associated with TP53 Arg homozygosity, not observed in CIN1-2 lesions (OR = 0.8, 95% CI: 0.1-5.1). Moreover, the frequency of the Arg homozygosity was similar in HIV-positive and HIV-negative groups. We conclude that TP53 Arg/Arg codon 72 genotype is a relevant risk factor for invasive squamous cell carcinoma of the conjunctiva and for CIN3 in the Ugandan population. Discussion: The absence of statistically significant difference in the distribution of TP53 Arg72 or Pro72 encoding alleles between HIV-positive and -negative subjects, affected by conjunctival neoplasia, suggests that HIV infection and/or the associated immunodeficiency represent further independent risk factors for ICSCC. © 2005 International Society for Preventive Oncology. Published by Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Tornesello, Maria Lina
Italy, Naples
Istituto Nazionale Tumori Irccs - Fondazione g Pascale, Napoli
Waddell, Keith M.
Uganda, Kampala
Uganda Eye Project
Duraturo, M. L.
Italy, Naples
Istituto Nazionale Tumori Irccs - Fondazione g Pascale, Napoli
Biryahwaho, Benon
Uganda, Entebbe
Uganda Virus Research Institute
Downing, Robert G.
Uganda, Entebbe
Uganda Virus Research Institute
Lucas, Sebastian B.
United Kingdom, London
St Thomas' Hospital
Giani, Umberto
Italy, Naples
Università Degli Studi Di Napoli Federico Ii, Facoltà Di Medicina e Chirurgia
Buonaguro, Luigi
Italy, Naples
Istituto Nazionale Tumori Irccs - Fondazione g Pascale, Napoli
Buonaguro, Franco Maria
Italy, Naples
Istituto Nazionale Tumori Irccs - Fondazione g Pascale, Napoli
Statistics
Citations: 21
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1016/j.cdp.2005.08.003
ISSN:
0361090X
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Study Locations
Uganda