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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Identification of hot spots of malaria transmission for targeted malaria control
Journal of Infectious Diseases, Volume 201, No. 11, Year 2010
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Description
Background. Variation in the risk of malaria within populations is a frequently described but poorly understood phenomenon. This heterogeneity creates opportunities for targeted interventions but only if hot spots of malaria transmission can be easily identified. Methods. We determined spatial patterns in malaria transmission in a district in northeastern Tanzania, using malaria incidence data from a cohort study involving infants and household-level mosquito sampling data. The parasite prevalence rates and age-specific seroconversion rates (SCRs) of antibodies against Plasmodium falciparum antigens were determined in samples obtained from people attending health care facilities. Results. Five clusters of higher malaria incidence were detected and interpreted as hot spots of transmission. These hot spots partially overlapped with clusters of higher mosquito exposure but could not be satisfactorily predicted by a probability model based on environmental factors. Small-scale local variation in malaria exposure was detected by parasite prevalence rates and SCR estimates for samples of health care facility attendees. SCR estimates were strongly associated with local malaria incidence rates and predicted hot spots of malaria transmission with 95% sensitivity and 85% specificity. Conclusions. Serological markers were able to detect spatial variation in malaria transmission at the microepidemiological level, and they have the potential to form an effective method for spatial targeting of malaria control efforts. © 2010 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Bousema, Teun
Unknown Affiliation
Drakeley, Chris J.
Unknown Affiliation
Gesase, Samwel
Unknown Affiliation
Hashim, Ramadhan
Unknown Affiliation
Magesa, Stephen Masingili
Unknown Affiliation
Mosha, Franklin W.
Unknown Affiliation
Otieno, Silas
Unknown Affiliation
Carneiro, Mona
Unknown Affiliation
Cox, Jonathan St H.
Unknown Affiliation
Msuya, Eliapendavyo
Unknown Affiliation
Kleinschmidt, Immo
Unknown Affiliation
Maxwell, Caroline A.
Unknown Affiliation
Greenwood, Brian M.
Unknown Affiliation
Riley, Eleanor M.
Unknown Affiliation
Sauerwein, Robert W.
Unknown Affiliation
Chandramohan, Daniel
Unknown Affiliation
Gosling, Roland D.
Unknown Affiliation
Statistics
Citations: 285
Authors: 17
Affiliations: 6
Identifiers
Doi:
10.1086/652456
ISSN:
00221899
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Tanzania