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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
LACK OF EFFICACY OF PYRIMETHAMINE PROPHYLAXIS IN PREGNANT NIGERIAN WOMEN
The Lancet, Volume 334, No. 8667, Year 1989
Notification
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Description
To evaluate the efficacy of pyrimethamine on the blood stage (suppressive prophylaxis) and liver stage (causal prophylaxis) of Plasmodium falciparum in pregnant women, in vivo and in vitro field studies were conducted in Ilorin, Nigeria, from Jan 1 to June 30, 1988. For pregnant women with P falciparum infections who received 25 mg of pyrimethamine weekly for suppressive prophylaxis, 67% (59/88) of in vivo and 60% (6/10) of in vitro tests showed pyrimethamine resistance. A second group of parasitaemic and parasite-free pregnant women was enrolled to evaluate the efficacy of pyrimethamine as a primary tissue schizonticide; after receiving a curative dose of chloroquine (25 mg/kg), half the women were given 25 mg of pyrimethamine weekly and half received no prophylaxis. Parasitologic failure rates did not differ between the pyrimethamine-treated (8/34) and the control (11/37) groups during the 16-week follow-up. Thus, pyrimethamine is not effective for suppressive or causal prophylaxis in pregnant women in Ilorin. © 1989.
Authors & Co-Authors
Nahlen, Bernard L.
United States, Atlanta
National Center for Infectious Diseases
Alakija, T.
Nigeria, Minna
Ministry of Health
Ogunbode, Olatoye O.
Nigeria, Ilorin
University of Ilorin
Adetoro, Olalekan O.
Nigeria, Ilorin
University of Ilorin
Akintunde, A.
Nigeria, Ilorin
University of Ilorin
Nguyen-Dinh, Phuc
United States, Atlanta
National Center for Infectious Diseases
Edungbola, Luke D.
Nigeria, Ilorin
University of Ilorin
Breman, Joel G.
United States, Atlanta
National Center for Infectious Diseases
Statistics
Citations: 46
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1016/S0140-6736(89)92998-X
ISSN:
01406736
Study Design
Cohort Study
Study Locations
Nigeria
Participants Gender
Female