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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Prevalence, incidence and clearance of human papillomavirus infection among young primiparous pregnant women in Kampala, Uganda
International Journal of Cancer, Volume 123, No. 9, Year 2008
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Description
The proportion of women who have already been exposed to human papillomavirus (HPV) infection by the time they first become pregnant, and the influence of pregnancy and delivery on the course of HPV infection are unclear. In Kampala, Uganda, 987 young primiparous pregnant women aged <25 years had gynaecological examination and liquid-based cytology. In the follow-up, women acted as their own controls, i.e., 1st/2nd versus 3rd trimesters (105 women), and during pregnancy versus after delivery (289 women). HPV was assessed using highly sensitive PCR assays. Prevalence of HPV and HIV infections at baseline were 60.0% and 7.3%, respectively. HPV16 and 18 were detected in 8.4% and 5.8%, respectively, i.e., less frequentlv than HPV51 (8.7%) and 52 (12.1%). At follow-up new HPV infections were detected in 42.9% of women between the lst/2nd and 3rd trimesters, and 38.1% between pregnancy and delivery, but 50.4% and 71.8% of HPV infections, respectively, cleared, leaving HPV prevalence unchanged in the different periods. Prevalence of cytological abnormalities diminished after delivery (from 21.2% to 12.4%). Presence of genital warts and sexually transmitted infections other than HPV were the strongest risk factors for prevalent or incident HPV infection. Clearance was lower among HIV-positive women. In conclusion, HPV prevalence was high in primiparous women in Uganda, but pregnancy did not seem to be a period of special vulnerability to the infection. © 2008 Wiley-Liss, Inc.
Authors & Co-Authors
Banura, Cecily
Uganda, Kampala
Makerere University
Sweden, Stockholm
Karolinska Institutet
Franceschi, Silvia F.
France, Lyon
Centre International de Recherche Sur le Cancer
van Doorn, Leen Jan
Netherlands, Voorburg
Ddl Diagnostic Laboratory
Arslan, Annie
France, Lyon
Centre International de Recherche Sur le Cancer
Kleter, Bernhard
Netherlands, Voorburg
Ddl Diagnostic Laboratory
Wabwire-Mangen, Fred
Uganda, Kampala
Makerere University
Mbidde, Edward Katongole
Uganda, Entebbe
Uganda Virus Research Institute
Quint, Wim G.V.
Netherlands, Voorburg
Ddl Diagnostic Laboratory
Weiderpass, Elisabete
Sweden, Stockholm
Karolinska Institutet
Norway, Oslo
Cancer Registry of Norway
Norway, Tromso
Uit Norges Arktiske Universitet
Finland, Helsinki
Folkhälsan
Statistics
Citations: 61
Authors: 9
Affiliations: 8
Identifiers
Doi:
10.1002/ijc.23762
ISSN:
00207136
e-ISSN:
10970215
Research Areas
Cancer
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Uganda
Participants Gender
Female