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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Antidepressant-like effect of Δ
9
-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L.
Pharmacology Biochemistry and Behavior, Volume 95, No. 4, Year 2010
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Description
The antidepressant action of cannabis as well as the interaction between antidepressants and the endocannabinoid system has been reported. This study was conducted to assess the antidepressant-like activity of Δ9-THC and other cannabinoids. Cannabinoids were initially evaluated in the mouse tetrad assay to determine doses that do not induce hypothermia or catalepsy. The automated mouse forced swim (FST) and tail suspension (TST) tests were used to determine antidepressant action. At doses lacking hypothermic and cataleptic effects (1.25, 2.5, and 5mg/kg, i.p.), both Δ9-THC and Δ8-THC showed a U-shaped dose response with only Δ9-THC showing significant antidepressant-like effects at 2.5mg/kg (p<0.05) in the FST. The cannabinoids cannabigerol (CBG) and cannabinol (CBN) did not produce antidepressant-like actions up to 80mg/kg in the mouse FST, while cannabichromene (CBC) and cannabidiol (CBD) exhibited significant effect at 20 and 200mg/kg, respectively (p<0.01). The antidepressant-like action of Δ9-THC and CBC was further confirmed in the TST. Δ9-THC exhibited the same U-shaped dose response with significant antidepressant-like action at 2.5mg/kg (p<0.05) while CBC resulted in a significant dose-dependent decrease in immobility at 40 and 80mg/kg doses (p<0.01). Results of this study show that Δ9-THC and other cannabinoids exert antidepressant-like actions, and thus may contribute to the overall mood-elevating properties of cannabis. © 2010.
Authors & Co-Authors
El-Alfy, Abir T.
United States, University
University of Mississippi
Ivey, Kelly
United States, University
University of Mississippi
Robinson, Keisha
United States, University
University of Mississippi
Ahmed, Safwat A.
United States, University
University of Mississippi School of Pharmacy
Egypt, Ismailia
Faculty of Pharmacy
Radwan, Mohamed M.
United States, University
University of Mississippi School of Pharmacy
Slade, Desmond
United States, University
University of Mississippi School of Pharmacy
Khan, Ikhlas A.
United States, University
University of Mississippi School of Pharmacy
United States, University
University of Mississippi
ElSohly, Mahmoud A.
United States, University
University of Mississippi School of Pharmacy
United States, University
University of Mississippi
Ross, Samir Anis
United States, University
University of Mississippi School of Pharmacy
United States, University
University of Mississippi
Statistics
Citations: 200
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1016/j.pbb.2010.03.004
ISSN:
00913057
Research Areas
Substance Abuse