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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Circulating Epstein-Barr virus in children living in malaria-endemic areas
Scandinavian Journal of Immunology, Volume 61, No. 5, Year 2005
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Description
Children living in malaria-endemic regions have high incidence of Burkitt's lymphoma (BL), the aetiology of which involves Plasmodium falciparum malaria and Epstein-Barr virus (EBV) infections. Acute malarial infection impairs the EBV-specific immune responses with the consequent increase in the number of EBV-carrying B cells in the circulation. To further understand the potential influence of malarial infection on the EBV persistence in children living in malaria-endemic areas, we studied the occurrence and quantified cell-free EBV-DNA in plasma from 73 Ghanaian children with and without acute malarial infection. Viral DNA was detected in 40% of the samples (47% in the malaria-infected and 34% in the nonmalaria group) but was absent in plasma from Ghanaian adults and healthy Italian children. These findings provide evidence that viral reactivation is common among children living in malaria-endemic areas, and may contribute to the increased risk for endemic BL. The data also suggest that the epidemiology of EBV infection and persistence varies in different areas of the world. © 2005 Blackwell Publishing Ltd.
Authors & Co-Authors
Rasti, N.
Sweden, Solna
Department of Microbiology, Tumor and Cell Biology
Falk, Kerstin Ingrid
Sweden, Solna
Department of Microbiology, Tumor and Cell Biology
Sweden, Stockholm
Karolinska Institutet
Donati, Daria
Sweden, Solna
Department of Microbiology, Tumor and Cell Biology
Sweden, Stockholm
Karolinska Universitetssjukhuset
Gyan, Ben Adu
Sweden, Stockholm
Stockholms Universitet
Goka, Bamenla Quarm
Ghana, Accra
University of Ghana
Troye-Blomberg, Marita
Sweden, Stockholm
Stockholms Universitet
Akanmori, Bartholomew Dicky
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Kurtzhals, J. A.L.
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Denmark, Copenhagen
Centre for Medical Parasitology
Dodoo, Daniel K.
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Consolini, Rita
Italy, Pisa
Università Di Pisa
Lindé, Annika
Sweden, Solna
Department of Microbiology, Tumor and Cell Biology
Sweden, Stockholm
Karolinska Institutet
Wahlgren, Mats
Sweden, Solna
Department of Microbiology, Tumor and Cell Biology
Bejarano, Maria Teresa
Sweden, Solna
Department of Microbiology, Tumor and Cell Biology
Sweden, Stockholm
Karolinska Universitetssjukhuset
Statistics
Citations: 88
Authors: 13
Affiliations: 8
Identifiers
Doi:
10.1111/j.1365-3083.2005.01589.x
ISSN:
03009475
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study