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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Vaccination coverage and timeliness in three South African areas: A prospective study
BMC Public Health, Volume 11, Article 404, Year 2011
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Description
Background: Timely vaccination is important to induce adequate protective immunity. We measured vaccination timeliness and vaccination coverage in three geographical areas in South Africa. Methods. This study used vaccination information from a community-based cluster-randomized trial promoting exclusive breastfeeding in three South African sites (Paarl in the Western Cape Province, and Umlazi and Rietvlei in KwaZulu-Natal) between 2006 and 2008. Five interview visits were carried out between birth and up to 2 years of age (median follow-up time 18 months), and 1137 children were included in the analysis. We used Kaplan-Meier time-to-event analysis to describe vaccination coverage and timeliness in line with the Expanded Program on Immunization for the first eight vaccines. This included Bacillus Calmette-Guérin (BCG), four oral polio vaccines and 3 doses of the pentavalent vaccine which protects against diphtheria, pertussis, tetanus, hepatitis B and Haemophilus influenzae type B. Results: The proportion receiving all these eight recommended vaccines were 94% in Paarl (95% confidence interval [CI] 91-96), 62% in Rietvlei (95%CI 54-68) and 88% in Umlazi (95%CI 84-91). Slightly fewer children received all vaccines within the recommended time periods. The situation was worst for the last pentavalent- and oral polio vaccines. The hazard ratio for incomplete vaccination was 7.2 (95%CI 4.7-11) for Rietvlei compared to Paarl. Conclusions: There were large differences between the different South African sites in terms of vaccination coverage and timeliness, with the poorer areas of Rietvlei performing worse than the better-off areas in Paarl. The vaccination coverage was lower for the vaccines given at an older age. There is a need for continued efforts to improve vaccination coverage and timeliness, in particular in rural areas. Trial registration number. © 2011 Fadnes et al; licensee BioMed Central Ltd.
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Authors & Co-Authors
Fadnes, Lars Thore
Norway, Bergen
Universitetet I Bergen
Jackson, Debra J.
South Africa, Bellville
University of the Western Cape
Engebretsen, Ingunn Marie Stadskleiv
Norway, Bergen
Universitetet I Bergen
Zembe-Mkabile, Wanga Z.
South Africa, Tygerberg
South African Medical Research Council
Sanders, David M.
South Africa, Tygerberg
South African Medical Research Council
Sommerfelt, Halvor
Norway, Bergen
Universitetet I Bergen
Norway, Oslo
Folkehelseinstituttet
Tylleskär, Thorkild
Norway, Bergen
Universitetet I Bergen
Statistics
Citations: 101
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1186/1471-2458-11-404
e-ISSN:
14712458
Research Areas
Environmental
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Randomised Control Trial
Cohort Study
Study Locations
South Africa