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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Cyclopalladated complexes containing tridentate thiosemicarbazone ligands of biological significance: Synthesis, structure and antimalarial activity
Journal of Organometallic Chemistry, Volume 695, No. 19-20, Year 2010
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Description
The C-H activation reaction of two aryl-derived thiosemicarbazones with K2[PdCl4] affords tetranuclear cyclopalladated complexes (3 and 4) where the thiosemicarbazone ligand acts as a tridentate donor [C,N,S] coordinated to palladium via the ortho-carbon of the aryl ring, imine nitrogen and thiolato sulfur. The palladium-sulfur bridging coordination bonds give rise to a Pd4S4 core. These Pd-Sbridging bonds were cleaved with a variety of mono-and bis-phosphines to give a series of mono, di and tetranuclear organopalladium complexes (5-12) where the phosphorus atom coordinates to palladium trans to the imine nitrogen. All of the complexes were fully characterized using various analytical and spectroscopic techniques. These palladium complexes along with their free ligands were evaluated as bioorganometallic antimalarial agents against two Plasmodium falciparum strains, 3D7 (chloroquine sensitive) and K1 (chloroquine and pyrimethamine resistant). Some of the complexes were found to be moderate inhibitors of parasite growth and were more active than the corresponding free ligand. © 2010 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Chellan, Prinessa
Unknown Affiliation
Nasser, Shereen
Unknown Affiliation
Vivas, Livia
Unknown Affiliation
Chibale, Kelly
Unknown Affiliation
Smith, Gregory S.
Unknown Affiliation
Statistics
Citations: 96
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.jorganchem.2010.06.010
ISSN:
0022328X
Research Areas
Environmental