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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Quantification of HIV-1 p24 by a highly improved ELISA: An alternative to HIV-1 RNA based treatment monitoring in patients from Abidjan, Côte d'Ivoire
Journal of Clinical Virology, Volume 37, No. 3, Year 2006
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Description
Background: Quantification of HIV-1 RNA remains difficult to implement in Africa. Simple and inexpensive tests for antiretroviral treatment (ART) monitoring are needed. Objective: To evaluate an HIV-1 p24 ELISA, which combines efficient virus disruption, heat-denaturation and signal amplification, in a West African setting. Study design: Eighty-six HIV-1 infected patients from Abidjan, Côte d'Ivoire, were tested for p24, HIV-1 RNA, and CD4+ count at baseline, and twice within 8 months after ART initiation. Results: All patients responded to ART with a minimal HIV-1 RNA drop of 0.5 log10 at first follow-up. Forty-one (47.7%) then rebounded >0.5 log10 or persisted above 1000 copies/mL by week 24. The predicted baseline concentration of p24 corresponding to 100,000 copies/mL of HIV-1 RNA, above which ART is recommended, was 4546 fg/mL (95% confidence interval 3148-6566). A prediction model of virologic failure, occurring after an initial response to ART, correctly classified 84% of patients using baseline p24, p24 change on therapy, and achievement of undetectable p24 as explanatory variables. The model and further bootstrap evaluation suggested a good ability to discriminate between sustained or failing virologic response to ART. Conclusion: HIV-1 p24 and RNA based-ART monitoring in a low-resource country dominated by HIV-1 CRF02 AG appeared comparable. © 2006 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Tehe, Andre
Cote D'ivoire, Abidjan
Project Retro-ci Abidjan
Maurice, Chantal E.
Cote D'ivoire, Abidjan
Project Retro-ci Abidjan
Hanson, Debra L.
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Borget, Marie Yolande
Cote D'ivoire, Abidjan
Project Retro-ci Abidjan
Abiola, Nadine
Cote D'ivoire, Abidjan
Project Retro-ci Abidjan
Maran, Matthieu
Cote D'ivoire, Abidjan
Project Retro-ci Abidjan
Yavo, Daniel
Cote D'ivoire, Abidjan
Project Retro-ci Abidjan
Tomasik, Zuzana
Switzerland, Zurich
Universität Zürich
Böni, Jürg
Switzerland, Zurich
Universität Zürich
Schüpbach, Jörg Rg
Switzerland, Zurich
Universität Zürich
N’kengasong, John Nkemngong
Cote D'ivoire, Abidjan
Project Retro-ci Abidjan
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Statistics
Citations: 20
Authors: 11
Affiliations: 3
Identifiers
Doi:
10.1016/j.jcv.2006.08.005
ISSN:
13866532
Research Areas
Infectious Diseases
Study Design
Cohort Study
Study Locations
Ivory Coast