Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Insulin resistance and the relationship between urinary Na
+
/K
+
and ambulatory blood pressure in a community of African ancestry
American Journal of Hypertension, Volume 26, No. 5, Year 2013
Notification
URL copied to clipboard!
Description
Background Although groups of African descent are particularly sensitive to blood pressure (BP) effects of salt intake, the role of obesity and insulin resistance in mediating this effect is uncertain. We determined whether obesity or insulin resistance is independently associated with urinary Na +/K+-BP relationships in a community sample of African ancestry. Methods We measured 24-hour urinary Na+/K+, homeostasis model assessment of insulin resistance (HOMA-IR), and nurse-derived conventional and 24-hour ambulatory BP in 331 participants from a South African community sample of black African descent not receiving treatment for hypertension. Results With adjustments for diabetes mellitus and the individual terms, an interaction between waist circumference and urinary Na +/K+ was associated with day diastolic BP (P < 0.05) and an interaction between log HOMA-IR and urinary Na+/K+ was associated with 24-hour and day systolic (P < 0.05) and 24-hour, day, and night diastolic (P < 0.002; P < 0.001) BP. The multivariable-adjusted relationship between urinary Na+/K+ and night diastolic BP increased across tertiles of HOMA-IR (tertile 1: β-coefficient =-0.79±0.47; tertile 2: β-coefficient = 0.65±0.35; tertile 3: β-coefficient = 1.03±0.46; P < 0.05 tertiles 3 and 2 vs. 1). The partial correlation coefficients for relationships between urinary Na +/K+ and 24-hour (partial r = 0.19; P < 0.02), day (partial r = 0.17; P < 0.05), and night (partial r = 0.18; P < 0.02) diastolic BP in participants with log HOMA-IR greater than or equal to the median were greater than those for relationships between urinary Na +/K+ and 24-hour (partial r =-0.08; P = 0.29), day (partial r =-0.10; P < 0.22), and night (partial r =-0.06; P = 0.40) diastolic BP in participants with log HOMA-IR less than the median (comparisons of r values: P < 0.05). Conclusions Insulin resistance may modify the relationship between salt intake, indexed by urinary Na+/K +, and ambulatory BP in groups of African descent. © 2013 American Journal of Hypertension, Ltd 2013. All rights reserved.
Authors & Co-Authors
Millen, Aletta M.E.
South Africa, Johannesburg
University of the Witwatersrand
Norton, Gavin R.
South Africa, Johannesburg
University of the Witwatersrand
Majane, Olebogeng H.I.
South Africa, Johannesburg
University of the Witwatersrand
Maseko, Muzi Joseph
South Africa, Johannesburg
University of the Witwatersrand
Brooksbank, Richard Leslie
South Africa, Johannesburg
University of the Witwatersrand
Michel, Frédéric S.
South Africa, Johannesburg
University of the Witwatersrand
Snyman, Tracy
South Africa, Johannesburg
School of Pathology
Sareli, Pinhas E.
South Africa, Johannesburg
University of the Witwatersrand
Woodiwiss, Angela Jill
South Africa, Johannesburg
University of the Witwatersrand
Statistics
Citations: 17
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1093/ajh/hpt010
ISSN:
08957061
e-ISSN:
19417225
Research Areas
Health System And Policy
Noncommunicable Diseases